Results 41 to 50 of about 8,067 (198)

Genetic tracing of Nav1.8‐expressing vagal afferents in the mouse [PDF]

Journal of Comparative Neurology, 2011
AbstractNav1.8 is a tetrodotoxin‐resistant sodium channel present in large subsets of peripheral sensory neurons, including both spinal and vagal afferents. In spinal afferents, Nav1.8 plays a key role in signaling different types of pain. Little is known, however, about the exact identity and role of Nav1.8‐expressing vagal neurons.
Laurent, Gautron, Ichiro, Sakata, Swalpa, Udit, Jeffrey M, Zigman, John N, Wood, Joel K, Elmquist   +5 more
openaire   +2 more sources

Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons

Scientific Reports, 2021
The inhibition of voltage-gated sodium (NaV) channels in somatosensory neurons presents a promising novel modality for the treatment of pain. However, the precise contribution of these channels to neuronal excitability, the cellular correlate of pain, is
Matthew Alsaloum, Julie I. R. Labau, Shujun Liu, Mark Estacion, Peng Zhao, Fadia Dib-Hajj, Stephen G. Waxman   +6 more
doaj   +1 more source

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

Frontiers in Pharmacology, 2022
Voltage-gated sodium channel NaV1.8 regulates transmission of pain signals to the brain. While NaV1.8 has the potential to serve as a drug target, the molecular mechanisms that shape NaV1.8 gating are not completely understood, particularly mechanisms ...
Kiran George, Diego Lopez-Mateos, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Tarek Mohamed Abd El-Aziz, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Ashlee H. Rowe, Ashlee H. Rowe   +18 more
doaj   +1 more source

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons [PDF]

, 2019
Previously we reported that a group of inflammatory mediators significantly enhanced resurgent currents in dorsal root ganglion neurons. To understand the underlying intracellular signaling mechanism, we investigated the effects of inhibition of ...
Cummins, Theodore R., Knopp, Kelly L., Krajewski, Jeffrey L., McDermott, Jeff S., Nisenbaum, Eric S., Tan, Zhi-Yong, Wu, Bin   +6 more
core   +1 more source

The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations

Frontiers in Molecular Neuroscience, 2021
Apart from the most prominent symptoms in Autism spectrum disorder (ASD), namely deficits in social interaction, communication and repetitive behavior, patients often show abnormal sensory reactivity to environmental stimuli.
Björn Heinrichs, Baowen Liu, Baowen Liu, Jin Zhang, Jannis E. Meents, Kim Le, Andelain Erickson, Petra Hautvast, Xiwen Zhu, Ningbo Li, Yi Liu, Yi Liu, Marc Spehr, Ute Habel, Ute Habel, Markus Rothermel, Barbara Namer, Xianwei Zhang, Angelika Lampert, Guangyou Duan   +19 more
doaj   +1 more source

Humanized Na_V1.8 rats overcome cross-species potency shifts in developing novel Na_V1.8 inhibitors. [PDF]

Neurobiol Pain
Voltage-gated sodium channel isoform 1.8 (NaV1.8) has emerged as a promising pharmaceutical target for the treatment of acute and chronic pain. However, highly selective and potent inhibitors for this channel have been difficult to develop and only recently have advanced to clinical testing.
McDevitt DS, Vardigan JD, Zhou X, Rosahl TW, Zhou H, Price EA, Clements MK, Li Y, Varghese N, Krasowska-Zoladek A, Stachel SJ, Breslin MJ, Burgey CS, Kraus RL, Pall PS, Henze DA, Santarelli VP.   +16 more
europepmc   +3 more sources

Activity and connectivity changes of central projection areas revealed by functional magnetic resonance imaging in NaV1.8-deficient mice upon cold signaling

Scientific Reports, 2017
The voltage-gated sodium channel subtype NaV1.8 is expressed in the peripheral nervous system in primary afferent nociceptive C-fibers and is essential for noxious cold signaling.
C. Heindl-Erdmann, K. Zimmermann, P. Reeh, K. Brune, A. Hess   +4 more
doaj   +1 more source

Возможный механизм лиганд-рецепторного связывания синтетического трипептида Ac-RRR-NH2 с мембраной ноцицептивного нейрона

Интегративная физиология, 2022
В мембране ноцицептивного нейрона нами был обнаружен новый сигнальный каскад опиоидоподобный рецептор → Na,K-ATФаза/ Src → канал NaV1.8. Запуск этого каскада приводит к модуляции его эффекторного звена — активационного воротного устройства канала NaV1.8,
Илья Вячеславович Рогачевский, Дмитрий Михайлович Самосват, Арина Дмитриевна Калинина, Георгий Георгиевич Зегря, Борис Владимирович Крылов, Светлана Александровна Подзорова, Вера Борисовна Плахова   +6 more
doaj   +1 more source

A disease mutation reveals a role for Nav1.9 in acute itch [PDF]

, 2018
Itch (pruritis) and pain represent two distinct sensory modalities; yet both have evolved to alert us to potentially harmful external stimuli. Compared with pain, our understanding of itch is still nascent.
Bosmans, Frank, Diaz-Bustamante, Marcelo, Dong, Xinzhong, Meixiong, James, Salvatierra, Juan, Tierney, Elaine   +5 more
core   +1 more source

The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model

Frontiers in Pharmacology, 2020
Atropine is commonly used to counter the effects of the parasympathetic neurotransmitter acetylcholine on heart rate in clinical practice, such as in the perioperative period; however, individual differences in the response to atropine are huge.
Baowen Liu, Baowen Liu, Ningbo Li, Jin Zhang, Yi Liu, Mi Zhang, Yishun Hong, Wenyao Wu, Xianwei Zhang, Guangyou Duan   +9 more
doaj   +1 more source