Results 61 to 70 of about 8,067 (198)

Therapeutic opportunities for targeting cold pain pathways [PDF]

, 2015
Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive.
Lewis, Richard J., Vetter, Irina, Yin, Kathleen, Zimmermann, Katharina   +3 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis.

PLoS ONE, 2015
Cerebellar symptoms significantly diminish quality of life in patients with multiple sclerosis (MS). We previously showed that sodium channel Nav1.8, although normally restricted to peripheral somatosensory neurons, is upregulated in the cerebellum in MS,
Shannon D Shields, Richard P Butt, Sulayman D Dib-Hajj, Stephen G Waxman   +3 more
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Selective Nav1.8 inhibition by suzetrigine, a novel nonopioid analgesic for acute pain management: A systematic review and metanalysis

Saudi Journal of Anaesthesia
Background: Suzetrigine, a novel nonopioid analgesic, selectively inhibits voltage-gated sodium channel 1.8 (NaV1.8) and has recently been approved for the management of moderate to severe acute pain. This meta-analysis aimed to evaluate the efficacy and
Sumit Bansal, Sunit Kumar Gupta, Siddhartha Dutta, Rima B. Shah, Shubha Singhal   +4 more
doaj   +1 more source

Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment

Neurobiology of Pain, 2022
Chronic pain arising from peripheral nerve injuries represents a significant clinical challenge because even the most efficacious anticonvulsant drug treatments are limited by their side effects profile.
Yatendra Mulpuri, Toru Yamamoto, Ichiro Nishimura, Igor Spigelman   +3 more
doaj   +1 more source

Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Sara A. Dochnal, Yixing Du, Daniella Bandari, Kaue Franco Malange, Jack Bryant, Julia Borges Paes Lemes, Abby Whitford, Anna R. Cliffe, Prashant Mali, Kim Dore, Yury I. Miller, Tony L. Yaksh   +11 more
wiley   +1 more source

NaV1.8: a novel contributor to cardiac arrhythmogenesis in heart failure

Cardiovascular Research, 2018
This editorial refers to ‘Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart’ by N. Dybkova et al., pp. 1728–1737.
Coppini, Raffaele, Ferrantini, Cecilia
openaire   +2 more sources

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

Chronic itch development in sensory neurons requires BRAF signaling pathways [PDF]

, 2013
Chronic itch, or pruritus, is associated with a wide range of skin abnormalities. The mechanisms responsible for chronic itch induction and persistence remain unclear.
Barry, Devin M., Battey, James F., Chen, Zhou-Feng, Cornelius, Lynn A., Demehri, Shadmehr, Hampton, Lori, Huo, Fu-Quan, Jeffry, Joseph, Kim, Seungil, Kopan, Raphael, Li, Hui, Liu, Xian-Yu, Liu, Zhong-Chun, Ma, Kaijie, Turkoz, Ahu, Wan, Li, Zhao, Zhong-Qiu, Zhong, Jian   +17 more
core   +2 more sources