Results 71 to 80 of about 8,067 (198)

Generation of homozygous Nav1.8 knock-out iPSC lines by CRISPR Cas9 genome editing to investigate a potential new antiarrhythmic strategy

Stem Cell Research, 2022
The sodium channel Nav1.8, encoded by SCN10A, is reported to contribute to arrhythmogenesis by inducing the late INa and thereby enhanced persistent Na+ current. However, its exact electrophysiological role in cardiomyocytes remains unclear.
Wiebke Maurer, Nico Hartmann, Loukas Argyriou, Samuel Sossalla, Katrin Streckfuss-Bömeke   +4 more
doaj   +1 more source

Gut microbiota and central nervous system's direct bidirectional regulation: The mechanisms of the gut–brain axis in irritable bowel syndrome

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Gut microbiota directly modulates central nervous system activity via vagal, sympathetic and sensory neural circuits. Brainstem nuclei integrate microbial signals to regulate gut motility, secretion and visceral sensitivity. DRG neurons and stress‐responsive pathways link microbial cues to host defence and epithelial homeostasis. Dysregulated gut–brain
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source

Increase in neuroexcitability of unmyelinated C-type vagal ganglion neurons during initial postnatal development of visceral afferent reflex functions [PDF]

, 2013
BACKGROUND: Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after
Cao, Pan‐Xiang, Han, Li‐Min, Li, Bai‐Yan, Li, Jun‐Nan, Liu, Dong‐Jie, Liu, Yang, Lu, Xiao‐Long, Pan, Xiao‐Dong, Qian, Zhao, Qiao, Guo‐Fen, Wang, Hao‐Yan, Wang, Li‐Juan, Xu, Bing, Yuan, Mei   +13 more
core   +2 more sources

Aberrant Molecular Myelin Architecture in Charcot–Marie–Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies

Glia, Volume 74, Issue 2, February 2026.
PMP22 copy number variation disrupts myelin architecture at SLIs and Nodes of Ranvier. Adherens junction and axoglial domain defects are often more severe in CMT1A than HNPP. Findings support PMP22 functioning as a structural organizer of myelin. ABSTRACT Charcot–Marie–Tooth Disease Type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure ...
Kathryn R. Moss, Marvis A. Arowolo, Dave R. Gutierrez, Ahmet Höke   +3 more
wiley   +1 more source

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant [PDF]

, 2014
Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone
Bajaj P, Dulin J, Farkas S, Fels G, Fujioka M, Funakoshi M, Funakoshi M, Gold R, Goldin A L, Hinck D, Hinck D, Hofer D, Kocsis P, Kocsis P, Kornelia Tekes, Lipták J, Luo Z, Melka A, Novales-Li P, Novales-Li P, Nádor K, Okada H, Ono H, Patel KS, Prabhoo R, Pratzel HG, Pórszász J, Quasthoff S, Quasthoff S, Rao R, Sakaue A, Sakitama K, Sakitama K, Stamenova P, Svensson P, Vora A, Zhao F   +36 more
core   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons [PDF]

, 2016
Nav1.6 and Nav1.6-mediated resurgent currents have been implicated in several pain pathologies. However, our knowledge of how fast resurgent currents are modulated in neurons is limited.
Barbosa, Cindy, Cummins, Theodore R., Johnson, Andrew J., Strong, Judith A., Xiao, Yucheng, Xie, Wenrui, Zhang, Jun-Ming   +6 more
core   +1 more source

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases [PDF]

, 2020
Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge.
Asano, Yoshihiro, Beerens, Manu, Burch, Micah L, Buys, Eva, Chiang, David Y, Cui, Shihe, Fujino, Noboru, Fujita, Takashi, Funada, Akira, Furusho, Hiroshi, Hayashi, Kenshi, Hodatsu, Akihiko, Inoue, Masaru, Kaku, Bunji, Kato, Takeshi, Kawashiri, Masa-aki, Kelly, Amy E, Kita, Yoshihito, Kiviniemi, Tuomas O, Kobayashi, Isao, Konno, Tetsuo, Kurata, Yasutaka, MacRae, Calum A, Nagata, Yoji, Nakanishi, Chiaki, Namura, Masanobu, Nomura, Akihiro, Oe, Kotaro, Okada, Hirofumi, Onoue, Kenji, Saito, Yoshihiko, Sakamoto, Yuichiro, Sakata, Kenji, Sips, Patrick, Tada, Hayato, Takamura, Masayuki, Takashima, Seiji, Takeda, Yuko, Tanaka, Yoshihiro, Teramoto, Ryota, Tsuchiya, Taketsugu, Tsuda, Toyonobu, Usuda, Keiich, Yamagishi, Masakazu, Zhao, Yanbin   +44 more
core   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. [PDF]

, 2017
Nociceptors are a subpopulation of dorsal root ganglia (DRG) neurons that detect noxious stimuli and signal pain. Veratridine (VTD) is a voltage-gated sodium channel (VGSC) modifier that is used as an "agonist" in functional screens for VGSC blockers ...
A Rambourg, A Wada, AA Harper, AJ Ren, C Lewis, C Virginio, CC Chen, CE Paulsen, CJ Liu, D Usoskin, DJ Cavanaugh, E Sigel, EJ Bradbury, G Collo, G Romey, J Lai, JA Verheugen, JL Biedler, JN Wood, JP Felix, JY Lou, KJ Farrag, L Djouhri, M Stevens, ME Barabas, R Schmidt, RP Seal, RW Teichert, RW Teichert, S Barnes, S Onizuka, SE Jordt, SG Lu, SG Waxman, SN Lawson, SN Lawson, T Hulsen, W Ulbricht, W Ulbricht, WD Snider, Z Cao   +40 more
core   +1 more source