The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility [PDF]
Channels, 2023 The Nav1.9 channel is a voltage-gated sodium channel. It plays a vital role in the generation of pain and the formation of neuronal hyperexcitability after inflammation. It is highly expressed in small diameter neurons of dorsal root ganglions and Dogiel
Chenyu Zhao, Xi Zhou, Xiaoliu Shi
doaj +4 more sources
Antinociceptive effects of AGAP, a recombinant neurotoxic polypeptide: Possible involvement of the tetrodotoxin-resistant sodium channels in small dorsal root ganglia neurons [PDF]
Frontiers in Pharmacology, 2016 Antitumor-analgesic peptide（AGAP）is a novel recombinant polypeptide. The primary study showed that AGAP 1.0 mg/kg exhibited strong analgesic and antitumor effects.
Li Chunli +7 more
doaj +2 more sources
Sodium channels as a new target for pain treatment [PDF]
Frontiers in PharmacologyVoltage-gated sodium channels, especially the Nav1.7, Nav1.8, and Nav1.9 subtypes, play a crucial role in the transmission of pain signals. Nav1.7 is considered a threshold channel that regulates the generation of action potentials and is closely ...
Rui Chen +6 more
doaj +2 more sources
Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons [PDF]
International Journal of Oral SciencePiezo2, a mechanosensitive ion channel, serves as a crucial mechanotransducer in dental primary afferent (DPA) neurons and is potentially involved in hypersensitivity to mild mechanical irritations observed in dental patients.
Pa Reum Lee +4 more
doaj +2 more sources
Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain [PDF]
Journal of Pharmaceutical AnalysisThis research study focuses on addressing the limitations of current neuropathic pain (NP) treatments by developing a novel dual-target modulator, E0199, targeting both NaV1.7, NaV1.8, and NaV1.9 and KV7 channels, a crucial regulator in controlling NP ...
Boxuan Zhang +14 more
doaj +2 more sources
Bone marrow mesenchymal stem cells attenuate pain and modulate peripheral sodium channel activity in a rat model of complex regional pain syndrome type I [PDF]
Cell TransplantationComplex Regional Pain Syndrome Type I (CRPS-I) is a chronic neuropathic pain disorder characterized by peripheral nerve hyperexcitability and altered nociceptive signaling.
Yuge Jiang +3 more
doaj +2 more sources
Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons [PDF]
BiomoleculesThe sigma-1 receptor (Sig-1R) has emerged as a significant target in the realm of pain management and has been the subject of extensive research. Nonetheless, its specific function in inflammatory pain within dorsal root ganglion (DRG) neurons remains ...
Yuanlong Song +3 more
doaj +2 more sources
Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice [PDF]
HereditasMas-related G protein-coupled receptors (Mrgs) are a subset of GPCRs linked to pain modulation. MrgF was identified as an orphan Mrg whose function and ligand remain unclear.
Xuejiao Chen +7 more
doaj +2 more sources
BMC Neuroscience, 2021 Background The SCN11A gene, encoded Nav1.9 TTX resistant sodium channels, is a main effector in peripheral inflammation related pain in nociceptive neurons. The role of SCN11A gene in the auditory system has not been well characterized.
Mian Zu +10 more
doaj +1 more source
Nav1.9 channel contributes to mechanical and heat pain hypersensitivity induced by subacute and chronic inflammation. [PDF]
PLoS ONE, 2011 Inflammation is known to be responsible for the sensitization of peripheral sensory neurons, leading to spontaneous pain and invalidating pain hypersensitivity.
Stéphane Lolignier +8 more
doaj +1 more source