Results 91 to 100 of about 3,773 (193)

Trigeminal neuralgia - diagnosis and treatment [PDF]

, 2017
Introduction Trigeminal neuralgia (TN) is characterized by touch-evoked unilateral brief shock-like paroxysmal pain in one or more divisions of the trigeminal nerve. In addition to the paroxysmal pain, some patients also have continuous pain.
Bendtsen, Lars, Cruccu, Giorgio, DI STEFANO, Giulia, Maarbjerg, Stine   +3 more
core   +1 more source

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Significant determinants of mouse pain behaviour.

PLoS ONE, 2014
Transgenic mouse behavioural analysis has furthered our understanding of the molecular and cellular mechanisms underlying damage sensing and pain. However, it is not unusual for conflicting data on the pain phenotypes of knockout mice to be generated by ...
Michael S Minett, Niels Eijkelkamp, John N Wood   +2 more
doaj   +1 more source

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways [PDF]

, 2013
Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin infusion and is thought to arise from a direct effect of oxaliplatin on peripheral sensory neurons.
Abrahamsen, Adelsberger, Alloui, Almeida, Argyriou, Attal, Bautista, Benoit, Burgess, Caldwell, Carr, Cersosimo, Colburn, Cox, de la Pena, Descoeur, Dhaka, Ehrsson, Fischer, Frankenhaeuser, Gauchan, Graham, Grolleau, Hensel, Jong, Kagiava, Krishnan, Leo, Ling, Liu, Luo, Madrid, Maingret, Nassini, Park, Peier, Rasband, Reid, Renn, Rush, Sakurai, Schafer, Schiavon, Shields, Sittl, Sittl, Story, Takeshita, Teichert, Vetter, Vetter, Viana, Wilson, Xiao, Yu, Zamudio, Zhang, Zhao, Zimmermann, Zimmermann   +59 more
core   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

The Role of Peripheral N‐Methyl‐D‐Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review

European Journal of Pain, Volume 29, Issue 7, August 2025.
ABSTRACT Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Emerging evidence suggests that peripheral NMDA receptors contribute to pathological pain and potentially ...
Ryusuke Tanaka, Silvia Lo Vecchio, Giulia Erica Aliotta, Lars Arendt‐Nielsen   +3 more
wiley   +1 more source

The M-Superfamily of Conotoxins: A Review [PDF]

, 2010
Throughout the world there exist both predator and prey. This distinction is apparent though sometimes misleading. Take for example marine snails of the genus Conus that are present across the oceans of the southern hemisphere [1].
Jacob, Reed B., McDougal, Owen M.
core   +2 more sources

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Effects of Tetrodotoxin on the Mammalian Cardiovascular System

Marine Drugs, 2010
The human genome encodes nine functional voltage-gated Na+ channels. Three of them, namely Nav1.5, Nav1.8, and Nav1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC50 ≥ 1 μM).
Thomas Zimmer
doaj   +1 more source

A Novel Function of NaV Channel β3 Subunit in Endothelial Cell Alignment Through Autophagy Modulation

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
Léa Réthoré, Anne‐Laure Guihot, Linda Grimaud, Coralyne Proux, Benjamin Barré, François Guillonneau, Catherine Guette, Alice Boissard, Cécile Henry, Jérôme Cayon, Rodolphe Perrot, Daniel Henrion, Christian Legros, Claire Legendre   +13 more
wiley   +1 more source