Results 101 to 110 of about 3,773 (193)

Novel Sodium Channel Inhibitor From Leeches

Frontiers in Pharmacology, 2018
Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function
Gan Wang, Chengbo Long, Weihui Liu, Cheng Xu, Min Zhang, Min Zhang, Qiong Li, Qiumin Lu, Qiumin Lu, Ping Meng, Dongsheng Li, Mingqiang Rong, Mingqiang Rong, Zhaohui Sun, Xiaodong Luo, Ren Lai, Ren Lai   +16 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, Volume 599, Issue 12, Page 1717-1732, June 2025.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Breaking the pain barrier: how suzetrigine and selective sodium channel blockers are reshaping the future of opioid-free analgesia

Quality in Sport
Introduction: Pain is a complex clinical challenge, with opioids traditionally used despite the risks of dependency and overdose. The need for safer alternatives has led to growing interest in voltage-gated sodium channels, particularly NaV1.7, NaV1.8 ...
Aleksandra Kaniak, Julia Andrzejewska, Kacper Forszt, Eliza Gawron, Paula Hauzer, Natalia Kulicka, Agata Ogórek, Alicja Osowska, Julianna Zielska, Dominika Ziółkowska   +9 more
doaj   +1 more source

Toxines et Transferts ioniques [PDF]

, 2011
Collection Rencontres en Toxinologie, ISSN 1760-6004 ; http://sfet.asso.fr/international/images/stories/SFET/pdf/Ebook-RT19-2011-signets.pdfInternational ...
Barbier, Julien, Benoit, Evelyne, Gilles, Nicolas, Ladant, Daniel, Martin-Eauclaire, Marie-France, Mattei, César, Molgó, Jordi, Popoff, Michel R., Servent, Denis   +8 more
core  

Editorial: Recent Advances in Voltage-Gated Sodium Channels, their Pharmacology and Related Diseases [PDF]

, 2016
No ...
Jean-François Desaphy, Mohamed Chahine
core   +3 more sources

Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]

, 2018
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique, Enrique, Nicolás Jorge, Gavernet, Luciana, Goicoechea, Sofia, Martín, Pedro, Milesi, Verónica, Palestro, Pablo Hernán, Sabatier, Laureano Leonel, Villalba, Maria Luisa   +8 more
core   +2 more sources

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons [PDF]

, 2015
BACKGROUND: Increased electrical activity in peripheral sensory neurons including dorsal root ganglia (DRG) and trigeminal ganglia neurons is an important mechanism underlying pain.
Barbosa, Cindy, Cummins, Theodore R., Patel, Reesha R., Strong, Judith A., Tan, Zhi-Yong, Vasko, Michael R., Wang, Ruizhong, Xie, Wenrui, Zhang, Jun-Ming   +8 more
core   +1 more source

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1

Marine Drugs, 2017
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus.
Filip Touska, Simon Sattler, Philipp Malsch, Richard J. Lewis, Peter W. Reeh, Katharina Zimmermann   +5 more
doaj   +1 more source

Na+ current expression in human atrial myofibroblasts: identity and functional roles [PDF]

, 2014
In the mammalian heart fibroblasts have important functional roles in both healthy conditions and diseased states. During pathophysiological challenges, a closely related myofibroblast cell population emerges, and can have distinct and significant roles ...
Colleen Kondo, Darrell Belke, Jussi T. Koivumäki, Mary M. C. Maleckar, Paul W. M. Fedak, Robert B. Clark, Wayne R. Giles   +6 more
core   +2 more sources

Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons. [PDF]

, 2003
Brain-derived neurotrophic factor (BDNF) promotes the biochemical and morphological differentiation of selective populations of neurons during development.
Allaman, I., Burkhalter, J., Chatton, J.Y., Fiumelli, H., Martin, J.L.   +4 more
core   +1 more source