Results 111 to 120 of about 3,773 (193)

Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Marine Drugs, 2016
Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Nav1.1–Nav1.9), Nav1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission ...
Fang Zhao, Xichun Li, Liang Jin, Fan Zhang, Masayuki Inoue, Boyang Yu, Zhengyu Cao   +6 more
doaj   +1 more source

The Role NaV1.9 in Somatosensory Signaling [PDF]

Biophysical Journal, 2018
Juan Salvatierra, Frank Bosmans, Marcelo Diaz-Bustamante, James Meixiong, Xinzhong Dong   +4 more
openaire   +1 more source

Correlation of the electrophysiological profiles and sodium channel transcripts of individual rat dorsal root ganglia neurons

Frontiers in Cellular Neuroscience, 2014
Voltage gated sodium channels (Na+ channels) play an important role in nociceptive transmission. They are intimately tied to the genesis and transmission of neuronal firing.
Olivier eTheriault, Mohamed eChahine
doaj   +1 more source

Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons [PDF]

, 2015
Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na(+)-dependent K(+) (K(Na)) channels. Progress in understanding K(Na) channels has been hampered by the absence of specific tools and methods for rigorous K(Na) identification in ...
Bader, Barcia, Berkefeld, Berkefeld, Bhattacharjee, Bhattacharjee, Bhattacharjee, Bischoff, Biton, Chahine, Chen, Cho, Coste, Dirajlal, Dobler, Dryer, Dryer, Fang, Franceschetti, Gao, Gribkoff, Hage, Heron, Hess, Ho, Huang, Kaczmarek, Kameyama, Kim, Kim, Lallemend, Li, Liu, Lu, Markham, Martin, Martinez-Espinosa, McNamara, Molliver, Nassar, Niu, Nuwer, Petruska, Rugiero, Safronov, Safronov, Schwindt, Shimada, Silverman, Strickland, Stucky, Sun, Tamsett, Vijayaragavan, Vydyanathan, Wallen, Yang, Yang, Yang, Yuan, Zhang, Zhang, Zhao, Zhao   +63 more
core   +2 more sources

Association of NaV1.8 with lipid rafts in DRG sensory neurons

, 2011
Voltage gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neuronal cells. NaV1.8 is a Tetrodotoxin resistant VGSC expressed in nociceptors and underlies the majority of sodium currents during action
Pristera, Alessandro, Pristera, Alessandro   +1 more
core   +1 more source

Behavior of ion channels controlled by electric potential difference and of Toll-type receptors in neuropathic pain pathophysiology

Revista Dor
BACKGROUND AND OBJECTIVES: Neuropathic pain is a severe and refractory medical condition, for which only partially effective treatments are currently available.
André Prato Schmidt, Sérgio Renato Guimarães Schmidt   +1 more
doaj   +1 more source

Analgesic effects of calcitonin on radicular pain in male rats

Journal of Pain Research, 2019
Yoshinori Terashima,1,2 Tsuneo Takebayashi,3 Shunsuke Jimbo,1 Izaya Ogon,1 Tatsuya Sato,2 Nobutoshi Ichise,2 Noritsugu Tohse,2 Toshihiko Yamashita1 1Department of Orthopaedic Surgery, School of Medicine, Sapporo Medical University, Sapporo 060-0061 ...
Terashima Y, Takebayashi T, Jimbo S, Ogon I, Sato T, Ichise N, Tohse N, Yamashita T   +7 more
doaj  

Nav1.9 (SCN11A) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera [PDF]

, 2015
Cold hypersensitivity is evident in a range of neuropathies and can evoke sensations of paradoxical burning cold pain. Ciguatoxin poisoning is known to induce a pain syndrome caused by consumption of contaminated tropical fish that can persist for months
Brice, NL, Dickenson, AH, Lewis, RJ, Patel, R   +3 more
core  

Voltage-gated membrane currents in neurons involved in odor information processing in snail procerebrum [PDF]

, 2013
Battonyai, Izabella, Elekes, Károly, Kiss, Tibor, Krajcs, Nóra, Pirger, Zsolt   +4 more
core   +1 more source