Results 11 to 20 of about 3,773 (193)

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9 [PDF]

Toxins, 2012
Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine
John Gilchrist, Frank Bosmans
doaj   +4 more sources

A disease mutation reveals a role for Nav1.9 in acute itch [PDF]

Journal of Clinical Investigation, 2018
Itch (pruritis) and pain represent two distinct sensory modalities; yet both have evolved to alert us to potentially harmful external stimuli. Compared with pain, our understanding of itch is still nascent.
Bosmans, Frank, Diaz-Bustamante, Marcelo, Dong, Xinzhong, Meixiong, James, Salvatierra, Juan, Tierney, Elaine   +5 more
core   +6 more sources

The Nav1.9 channel regulates colonic motility in mice [PDF]

Frontiers in Neuroscience, 2013
The colonic migrating motor complex (CMMC) is a major pattern of motility that is entirely generated and organized by the enteric nervous system (ENS). We have previously demonstrated that the Nav1.9 channel underlies a tetrodotoxin-resistant Na+ current
Carine eCopel, Nadine eClerc, Nancy eOsorio, Patrick eDelmas, Bruno eMazet   +4 more
doaj   +4 more sources

A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain [PDF]

Frontiers in Neuroscience, 2019
Voltage-gated sodium channel Nav1.9 is a threshold channel that regulates action potential firing. Nav1.9 is preferentially expressed in myenteric neurons, and small-diameter dorsal root ganglion (DRG) and trigeminal ganglion neurons including ...
Jianying Huang, Jianying Huang, Mark Estacion, Mark Estacion, Peng Zhao, Peng Zhao, Fadia B. Dib-Hajj, Fadia B. Dib-Hajj, Betsy Schulman, Betsy Schulman, Angela Abicht, Angela Abicht, Ingo Kurth, Knut Brockmann, Stephen G. Waxman, Stephen G. Waxman, Sulayman D. Dib-Hajj, Sulayman D. Dib-Hajj   +17 more
doaj   +6 more sources

Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

PLoS ONE, 2018
We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these ...
Risako Kabata, Hiroko Okuda, Atsuko Noguchi, Daiki Kondo, Michimasa Fujiwara, Kenichiro Hata, Yoshifumi Kato, Ken Ishikawa, Manabu Tanaka, Yuji Sekine, Nozomi Hishikawa, Tomoyuki Mizukami, Junichi Ito, Manami Akasaka, Ken Sakurai, Takeshi Yoshida, Hironori Minoura, Takashi Hayashi, Kohei Inoshita, Misayo Matsuyama, Noriko Kinjo, Yang Cao, Sumiko Inoue, Hatasu Kobayashi, Kouji H Harada, Shohab Youssefian, Tsutomu Takahashi, Akio Koizumi   +27 more
doaj   +4 more sources

The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia

Cell Reports, 2015
Cold-triggered pain is essential to avoid prolonged exposure to harmfully low temperatures. However, the molecular basis of noxious cold sensing in mammals is still not completely understood.
Stéphane Lolignier, Caroline Bonnet, Christelle Gaudioso, Jacques Noël, Jérôme Ruel, Muriel Amsalem, Jérémy Ferrier, Lise Rodat-Despoix, Valentine Bouvier, Youssef Aissouni, Laetitia Prival, Eric Chapuy, Françoise Padilla, Alain Eschalier, Patrick Delmas, Jérôme Busserolles   +15 more
doaj   +4 more sources

Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment. [PDF]

J Comp Neurol
Various sodium channel isoforms and their scaffolding proteins are found in four different microdomains in vestibular calyx‐bearing afferents. These microdomains serve different purposes, analogous to the heminode, axon initial segment, and synaptic domains of other types of sensory afferents.
Lysakowski A, Govindaraju AC, Price SD, Gaboyard-Niay S, Calin-Jageman I, Chidavaenzi RL, Eatock RA, Raphael RM, Goldberg JM.   +8 more
europepmc   +2 more sources

The para^bss1 Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects. [PDF]

Eur J Pain
ABSTRACT Background Chronic pain, which is often unrelated to ongoing injury, is poorly understood and difficult to treat. Genetic studies have identified voltage‐gated sodium (Nav) channels, particularly gain‐of‐function mutations such as L858F and R1150W in human NaV1.7, as involved in the development of chronic pain. Methods A chronic pain model was
Malta SM, Correia LIV, Marquez AS, Bernardes LMM, Howland JG, Mendes-Silva AP, Espíndola FS, Ueira-Vieira C.   +7 more
europepmc   +2 more sources

Contusive spinal cord injury causes Nav1.8 dysfunction to upregulate small sensory neuron excitability. [PDF]

J Physiol
Abstract figure legend Contusive SCI significantly dysregulated excitability of small DRG neurons by enhancing Nav1.8 function. SCI‐induced hyperexcitability was partially reversed by ZL0177, a small compound disrupting FHF interaction with Nav1.8 and Nav1.9.
Xiao Y, Pan Y, Liu N, Cummins TR.
europepmc   +2 more sources

Le canal Nav1.9 [PDF]

médecine/sciences, 2016
La capacite des organismes a ressentir et integrer les informations provenant de leur environnement est apparue tres tot dans l’evolution et a fait l’objet d’une selection naturelle constante. Cela a permis l’emergence d’un systeme sensoriel dedie a la perception des stimulus potentiellement dangereux (nocifs) de par leur nature ou leur intensite.
Stéphane Lolignier, Alain Eschalier, Caroline Bonnet, Patrick Delmas, Jérôme Busserolles   +4 more
openaire   +2 more sources