A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels
eLife, 2022 Resurgent currents (INaR) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the first time, that INaR can
Yucheng Xiao +5 more
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Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol +6 more
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Marine Drugs, 2010 Sensory neurons in the dorsal root ganglion express two kinds of tetrodotoxin resistant (TTX-R) isoforms of voltage-gated sodium channels, NaV1.8 and NaV1.9. These isoforms play key roles in the pathophysiology of chronic pain.
Nobukuni Ogata +3 more
doaj +1 more source
The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia [PDF]
, 2015 BACKGROUND: Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Kopach, O +3 more
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Defining the Voltage Sensor Properties and Pharmacology of Nav1.9 [PDF]
Biophysical Journal, 2010 The voltage-activated sodium channel Nav1.9 is preferentially expressed in DRG neurons where it is believed to play an important role in pain perception. However, progress in revealing the gating characteristics and pharmacological sensitivities of Nav1.9 has been slow because attempts to express this channel in a heterologous expression system have ...
Bosmans, Frank +4 more
openaire +1 more source
Association between Tetrodotoxin Resistant Channels and Lipid Rafts Regulates Sensory Neuron Excitability [PDF]
, 2012 PubMed ID: 22870192This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Baker, MD, Okuse, K, Pristera, A
core +6 more sources
Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors [PDF]
, 2013 The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception.
Bean, Bruce Palmer +4 more
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Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
AlQatari, M +3 more
core +1 more source
P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors [PDF]
, 2016 Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders.
Baker, MD +11 more
core +1 more source
Suzetrigine, a Non-Opioid Small-Molecule Analgesic: Mechanism of Action, Clinical, and Translational Science. [PDF]
Clin Transl SciABSTRACT The discovery and approval of Suzetrigine (VX‐548, Journavx) marks a significant breakthrough in pain management. It is the first non‐opioid analgesic approved since celecoxib in 1998. Suzetrigine selectively blocks voltage‐gated sodium channel Nav1.8 and acts exclusively on peripheral nociceptors without crossing the blood–brain barrier ...
Rajasingham R, Qi Y.
europepmc +2 more sources