Results 61 to 70 of about 3,773 (193)

The Gain-of-Function R222S Variant in Scn11a Contributes to Visceral Hyperalgesia and Intestinal Dysmotility in Scn11aR222S/R222S Mice

Frontiers in Neurology, 2022
BackgroundThe SCN11A gene encodes the α-subunit of the Nav1. 9 channel, which is a regulator of primary sensory neuron excitability. Nav1.9 channels play a key role in somatalgia. Humans with the gain-of-function mutation R222S in SCN11A exhibit familial
Chenyu Zhao, Chenyu Zhao, Jishuo Jin, Jishuo Jin, Haoye Hu, Xi Zhou, Xiaoliu Shi   +6 more
doaj   +1 more source

Nav1.9 regulates bladder capacity in cyclophosphamide‐induced overactive bladder

The FASEB Journal, 2006
We have recently confirmed Nav1.9 as the molecular entity underlying the persistent, tetrodotoxin‐resistant, voltage‐gated Na + current in small diameter dorsal root ganglion neurons, and have demonstrated a functional role for Nav1.9 in the maintenance of inflammation‐induced hyperalgesia ...
Kevin Thorneloe, Amy M Ritter, Birgit T Priest, William J Martin   +3 more
openaire   +1 more source

Voltage-gated sodium channel expression in mouse DRG after SNI leads to re-evaluation of projections of injured fibers. [PDF]

, 2014
BACKGROUND: Dysregulation of voltage-gated sodium channels (Na(v)s) is believed to play a major role in nerve fiber hyperexcitability associated with neuropathic pain.
Decosterd, I., Laedermann, C.J., Pertin, M., Suter, M.R.   +3 more
core   +1 more source

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. [PDF]

, 2016
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors.
Alexandrou, AJ, Brown, AR, Butt, RP, Castle, NA, Chapman, ML, Cox, PJ, Dib-Hajj, SD, Doyle, R, Estacion, M, Gutteridge, A, Hounshell, JA, Krafte, D, Lin, Z, Marron, BE, Mis, MA, Patel, MK, Payne, EC, Printzenhoff, D, Randall, A, Rivara, M, Stevens, EB, Storer, RI, Stupple, PA, Swain, NA, Turner, J, Waxman, SG, West, C, Wilbrey, A   +27 more
core   +1 more source

Aberrant Molecular Myelin Architecture in Charcot–Marie–Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies

Glia, Volume 74, Issue 2, February 2026.
PMP22 copy number variation disrupts myelin architecture at SLIs and Nodes of Ranvier. Adherens junction and axoglial domain defects are often more severe in CMT1A than HNPP. Findings support PMP22 functioning as a structural organizer of myelin. ABSTRACT Charcot–Marie–Tooth Disease Type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure ...
Kathryn R. Moss, Marvis A. Arowolo, Dave R. Gutierrez, Ahmet Höke   +3 more
wiley   +1 more source

Expression of NaV1.9 channels by muscle afferent neurons (1129.10)

The FASEB Journal, 2014
Background: The exercise pressor reflex helps regulate cardiovascular responses to exercise. The voltage‐gated sodium channel (Nav) 1.9 has unique properties that could help to generate excessive neuronal activity. We have previously demonstrated the presence of Nav1.9 channels using antibody staining of identified neurons, but were not able to ...
Tyler Marler, Keith Elmslie
openaire   +1 more source

Membrane cholesterol depletion as a trigger of Nav1.9 channel‐mediated inflammatory pain [PDF]

The EMBO Journal, 2018
Cholesterol is a major lipid component of the mammalian plasma membrane. While much is known about its metabolism, its transport, and its role in atherosclerotic vascular disease, less is known about its role in neuronal pathophysiology. This study reveals an unexpected function of cholesterol in controlling pain transmission. We show that inflammation
Muriel Amsalem, Corinne Poilbout, Géraldine Ferracci, Patrick Delmas, Francoise Padilla   +4 more
openaire   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Isolation and transfection of myenteric neurons from mice for patch-clamp applications

Frontiers in Molecular Neuroscience, 2022
The enteric nervous system (ENS) is a complex neuronal network organized in ganglionated plexuses that extend along the entire length of the gastrointestinal tract.
Samuel Kuehs, Laura Teege, Ann-Katrin Hellberg, Christina Stanke, Natja Haag, Natja Haag, Ingo Kurth, Robert Blum, Carla Nau, Enrico Leipold   +9 more
doaj   +1 more source

Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels [PDF]

, 2015
Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes.
Alessandro eMedoro, Francesco eMiceli, Laura eManocchio, Maria Virginia eSoldovieri, Maurizio eTaglialatela, Maurizio eTaglialatela, Michela eDe Maria, Paolo eAmbrosino   +7 more
core   +2 more sources