Results 71 to 80 of about 3,773 (193)

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache

Nature Communications, 2019
The precise mechanisms that lead to medication-overuse headaches (MOH), which can occur with both over-the-counter and prescription pain-relief medicines, are still uncertain.
Caroline Bonnet, Jizhe Hao, Nancy Osorio, Anne Donnet, Virginie Penalba, Jérôme Ruel, Patrick Delmas   +6 more
doaj   +1 more source

Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia [PDF]

, 2017
Automated patch clamp (APC) technology was first developed at the turn of the millennium. The increased throughput it afforded promised a new paradigm in ion channel recordings: it offered the potential to overcome the time-consuming, low-throughput ...
Alexander, Alexander, Alexander, Alexander, Alexandrou, Arias, Asmild, Bagal, Becker, Bridgland-Taylor, Brinkwirth, Brüggemann, Cao, Castle, Chambard, Chambers, Dale, Danker, Deuis, Dunlop, Dunlop, Enna, Estacion, Fertig, Finkel, Friis, Gilbert, Gillie, Golden, Hamill, Hao, Haraguchi, Haythornthwaite, Ji, Kahle, Kao, Kauthale, Klement, Klint, Knabl, Kornecook, Kumar, Kuryshev, Lepple-Wienhues, Lin, Mathes, Mathes, Mathie, Miller, Milligan, Obergrussberger, Obergrussberger, Papakosta, Payne, Perkel, Sakmann, Sauter, Scheel, Schroeder, Shcherbatko, Shcherbatko, Sorota, Southan, Southan, Spencer, Stannard, Stoelzle, Swensen, Tao, Terstappen, Tibbs, Trivedi, Vasilyev, Windley, Xie, Xu, Xu   +76 more
core   +1 more source

Morpho‐Histo‐Cytological Evaluation of Oral Tissues in Burning Mouth Syndrome: A Systematic Review

Journal of Oral Rehabilitation, Volume 52, Issue 12, Page 2449-2480, December 2025.
This systematic review on Burning Mouth Syndrome (BMS) included 14 studies that examined histological changes. 12 studies used incisional biopsies and 2 used exfoliative cytology. Histology and molecular biology techniques were used to assess morphological, phenotypical and genomic changes in oral tissues, primarily from the tongue.
André Luís Porporatti, Ângela Graciela Deliga Schroder, Ashley Lebel, Nathan Moreau, Annabelle Réaux‐Le Goazigo, Ihsène Taïhi, Heike Rittner, Tara Renton, Yves Boucher   +8 more
wiley   +1 more source

SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing. [PDF]

PLoS ONE, 2016
Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia.
Andreas M Kist, Dagrun Sagafos, Anthony M Rush, Cristian Neacsu, Esther Eberhardt, Roland Schmidt, Lars Kristian Lunden, Kristin Ørstavik, Luisa Kaluza, Jannis Meents, Zhiping Zhang, Thomas Hedley Carr, Hugh Salter, David Malinowsky, Patrik Wollberg, Johannes Krupp, Inge Petter Kleggetveit, Martin Schmelz, Ellen Jørum, Angelika Lampert, Barbara Namer   +20 more
doaj   +1 more source

Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. [PDF]

, 2007
Ionic channel activity is involved in fundamental cellular behaviour and participates in cancerous features such as proliferation, migration and invasion which in turn contribute to the metastatic process.
Barascu, Aurélia, Besson, Pierre, Bougnoux, Philippe, Gruel, Yves, Iochmann, Sophie, Le Guennec, Jean-Yves, Lei, Ming, Raynal, Pierre-Ivan, Roger, Sébastien, Rollin, Jérôme   +9 more
core   +3 more sources

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

ChemMedChem, Volume 20, Issue 20, October 15, 2025.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean‐François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P [PDF]

European Journal of Human Genetics, 2014
Individuals with congenital insensitivity to pain (CIP) have never felt pain despite possessing an anatomically normal peripheral nervous system and normal intelligence.1 In 2006/7, biallelic null mutations in the transmembrane voltage-gated sodium channel NaV1.7/SCN9A were discovered as a cause of CIP.2, 3 Recently, a new form of CIP was reported in ...
Christopher Geoffrey, Woods, Mohamed Osman Eltahir, Babiker, Iain, Horrocks, John, Tolmie, Ingo, Kurth   +4 more
openaire   +2 more sources

NaV1.6 and NaV1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells.

PLoS ONE, 2019
ND7/23 cells are gaining traction as a host model to express peripheral sodium channels such as NaV1.8 and NaV1.9 that have been difficult to express in widely utilized heterologous cells, like CHO and HEK293.
Jisoo Lee, Shinae Kim, Hye-Mi Kim, Hyun Jeong Kim, Frank H Yu   +4 more
doaj   +1 more source

Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype

Frontiers in Medicine, 2018
Background: Hypoalgesic inflammatory bowel disease (IBD), a condition in which patients with active disease do not perceive and/or report abdominal pain, is associated with serious complications and there is a lack of cost-effective, reliable diagnostic ...
Eugene Gonzalez-Lopez, Yuka Imamura Kawasawa, Vonn Walter, Lijun Zhang, Walter A. Koltun, Xuemei Huang, Kent E. Vrana, Matthew D. Coates   +7 more
doaj   +1 more source