Results 81 to 90 of about 3,773 (193)

Increase in neuroexcitability of unmyelinated C-type vagal ganglion neurons during initial postnatal development of visceral afferent reflex functions [PDF]

, 2013
BACKGROUND: Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after
Cao, Pan‐Xiang, Han, Li‐Min, Li, Bai‐Yan, Li, Jun‐Nan, Liu, Dong‐Jie, Liu, Yang, Lu, Xiao‐Long, Pan, Xiao‐Dong, Qian, Zhao, Qiao, Guo‐Fen, Wang, Hao‐Yan, Wang, Li‐Juan, Xu, Bing, Yuan, Mei   +13 more
core   +2 more sources

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, Volume 9, Issue 10, October 2025.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

Sophisticated sperm allocation in male fowl [PDF]

, 2003
When a female is sexually promiscuous, the ejaculates of different males compete for the fertilization of her eggs; the more sperm a male inseminates into a female, the more likely he is to fertilize her eggs.
Pizzari, T., Cornwallis, C.K., Lovlie, H., Jakobssen, S., Birkhead, T.R.   +4 more
core   +1 more source

Purification and Characterization of JZTx-14, a Potent Antagonist of Mammalian and Prokaryotic Voltage-Gated Sodium Channels

Toxins, 2018
Exploring the interaction of ligands with voltage-gated sodium channels (NaVs) has advanced our understanding of their pharmacology. Herein, we report the purification and characterization of a novel non-selective mammalian and bacterial NaVs toxin, JZTx-
Jie Zhang, Dongfang Tang, Shuangyu Liu, Haoliang Hu, Songping Liang, Cheng Tang, Zhonghua Liu   +6 more
doaj   +1 more source

VGSC-DB: an online database of voltage-gated sodium channels

Journal of Cheminformatics, 2022
As an important member of ion channels family, the voltage-gated sodium channel (VGSC/Nav) is associated with a variety of diseases, including epilepsy, migraine, ataxia, etc., and has always been a hot target for drug design and discovery.
Gaoang Wang, Jiahui Yu, Hongyan Du, Chao Shen, Xujun Zhang, Yifei Liu, Yangyang Zhang, Dongsheng Cao, Peichen Pan, Tingjun Hou   +9 more
doaj   +1 more source

Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. [PDF]

, 2017
Nociceptors are a subpopulation of dorsal root ganglia (DRG) neurons that detect noxious stimuli and signal pain. Veratridine (VTD) is a voltage-gated sodium channel (VGSC) modifier that is used as an "agonist" in functional screens for VGSC blockers ...
A Rambourg, A Wada, AA Harper, AJ Ren, C Lewis, C Virginio, CC Chen, CE Paulsen, CJ Liu, D Usoskin, DJ Cavanaugh, E Sigel, EJ Bradbury, G Collo, G Romey, J Lai, JA Verheugen, JL Biedler, JN Wood, JP Felix, JY Lou, KJ Farrag, L Djouhri, M Stevens, ME Barabas, R Schmidt, RP Seal, RW Teichert, RW Teichert, S Barnes, S Onizuka, SE Jordt, SG Lu, SG Waxman, SN Lawson, SN Lawson, T Hulsen, W Ulbricht, W Ulbricht, WD Snider, Z Cao   +40 more
core   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
James Melrose, Stone Sima, Neha Chopra, Ashish Diwan, Zi Gu   +4 more
wiley   +1 more source

Therapeutic opportunities for targeting cold pain pathways [PDF]

, 2015
Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive.
Lewis, Richard J., Vetter, Irina, Yin, Kathleen, Zimmermann, Katharina   +3 more
core   +1 more source

5‐HT7 antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity

The Journal of Physiology, Volume 603, Issue 17, Page 4723-4745, September 1, 2025.
Abstract figure legend Schematic diagram of intestinal nerve abnormality underlying the mechanisms of visceral hypersensitivity. In physiological conditions with normal sensation, enteric neurons are situated in the submucosal and myenteric plexuses, and the spinal afferent fibres ramify within the enteric plexus. However, serotonin/5‐hydroxytryptamine
Tzu‐Yi Lee, Yu‐Hsuan Lin, Wen‐Ying Chang, Li‐Yu Lin, Che‐Feng Chang, Wei‐Ting Kuo, Chia‐Hung Tu, Ming‐Shiang Wu, Ling‐Wei Hsin, Linda Chia‐Hui Yu   +9 more
wiley   +1 more source

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms

Cell Reports, 2014
Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain.
Michael S. Minett, Sarah Falk, Sonia Santana-Varela, Yury D. Bogdanov, Mohammed A. Nassar, Anne-Marie Heegaard, John N. Wood   +6 more
doaj   +1 more source