Results 71 to 80 of about 3,927,016 (290)

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

A Mouse in vivo Model Mimicking MASH-Related HCC Pathogenesis

Journal of Hepatocellular Carcinoma
Tianxiao Zheng,1,2,* Zhi Pei,1,2,* Enze Cui,1,2 Luyuan Zhu,1,2 Juan Du,1,2 Changquan Ling1,2 1Department of Traditional Chinese Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People’s Republic of ...
Zheng T, Pei Z, Cui E, Zhu L, Du J, Ling C   +5 more
doaj  

Gelsolin regulates intestinal stem cell regeneration and Th17 cellular function

Cell Communication and Signaling
Intestinal stem cells (ISCs) are responsible for intestinal homeostasis and are important for the regeneration of damaged intestine. We established an ionizing radiation (IR)-induced intestinal injury model and observed that Gelsolin KO mice had ...
Jicong Du, Lan Fang, Yuedong Wang, Jianpeng Zhao, Zhenlan Feng, Yike Yu, Duo Fang, Daqian Huang, Xuanlu Zhai, Ying Cheng, Rui Min, Fu Gao, Cong Liu   +12 more
doaj   +1 more source

Toxic effects of permethrin on HMC3 microglia and its associated mechanism

环境与职业医学
BackgroundPermethrin is a commonly used pyrethroid insecticide and has been found to be potentially neurotoxic. Microglia are innate immune cells in the central nervous system and are involved in the development of a range of neurodegenerative diseases ...
Wanli ZHANG, Wenqi SHAN, Chao CHEN, Haowei DONG, Hao YUAN, Qiuming ZHOU, Feng TAO, Heng PENG, Yajun MA   +8 more
doaj   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials

Journal of Pain Research
Xiaonan Huang,1,* Shan Tian,2,* Lifan Xu,1,* Juhan Chen,1,* Hao Wang,3 Tingting Mai,1 Lei Shi,1 Han Wang,4 Mengcheng Cai,5 Fanfu Fang1 1Department of Rehabilitation Medicine, Changhai Hospital, Naval Medical University ...
Huang X, Tian S, Xu L, Chen J, Wang H, Mai T, Shi L, Wang H, Cai M, Fang F   +9 more
doaj  

Experiments on Nonlocal Fluid‐Flow Metamaterials

Advanced Science, EarlyView.
A nonlocal fluid‐flow metamaterial composed of standard microfluidic tubes and connectors is designed. Hence, the current of the system at one position depends on the gradient of fluid flow at many other positions, leading to unusual alternating backward and forward laminar flows of water.
Ke Wang, Yi Chen, Martin Wegener
wiley   +1 more source

Naval Research Working Group (NRWG) 17 [PDF]

, 2017
The Naval Postgraduate School (NPS) hosted the Naval Research Working Group (NRWG) 17 April 18-20, 2017 aboard the Monterey campus. This activity is an essential element in the success of the NPS Naval Research Program, as envisioned by the Secretary of ...
Naval Postgraduate School Naval Research Working Group
core   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source