Results 71 to 80 of about 3,107,422 (278)

A Mouse in vivo Model Mimicking MASH-Related HCC Pathogenesis

Journal of Hepatocellular Carcinoma
Tianxiao Zheng,1,2,* Zhi Pei,1,2,* Enze Cui,1,2 Luyuan Zhu,1,2 Juan Du,1,2 Changquan Ling1,2 1Department of Traditional Chinese Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, People’s Republic of ...
Zheng T, Pei Z, Cui E, Zhu L, Du J, Ling C   +5 more
doaj  

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials

Journal of Pain Research
Xiaonan Huang,1,* Shan Tian,2,* Lifan Xu,1,* Juhan Chen,1,* Hao Wang,3 Tingting Mai,1 Lei Shi,1 Han Wang,4 Mengcheng Cai,5 Fanfu Fang1 1Department of Rehabilitation Medicine, Changhai Hospital, Naval Medical University ...
Huang X, Tian S, Xu L, Chen J, Wang H, Mai T, Shi L, Wang H, Cai M, Fang F   +9 more
doaj  

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Experimental Naval Hydrodynamics Lab [PDF]

, 2018
Naval Research Program NRWG ...
Kwon, Young, Whitmer, Andrew, Klamo, Joseph, Didoszak, Jarema, Suriben, Kristia, Turner, Travis, Jones, Leo   +6 more
core  

Guidelines for High‐Throughput Screening for Natural Products With Anti‐Aging Activity Based on Drosophila Intestinal Homeostasis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Aging represents a critical risk factor for chronic diseases, driving an urgent demand for interventions promoting healthy longevity. This study establishes standardized guidelines for high‐throughput screening (HTS) of anti‐aging natural products using Drosophila melanogaster, leveraging its intestinal homeostasis as a biomarker.
Xiao Sheng, Lei Zhang
wiley   +1 more source

Characteristic Gut Microbiota in PCOS-IR Patients and Its Association with Endocrine Features

Diabetes, Metabolic Syndrome and Obesity
Wenyi Liang,1,* Yanning Yao,2,* Xinyang Ren,3 Anran Xue,4 Mengcheng Cai,2 Jin Yu,2 Chaoqin Yu,2 Ling Zhou,2 DongXia Zhai2 1School of Pharmacy, Naval Medical University, Shanghai, People’s Republic of China; 2Department of Gynecology of ...
Liang W, Yao Y, Ren X, Xue A, Cai M, Yu J, Yu C, Zhou L, Zhai D   +8 more
doaj  

The role of NINJ1 in diseases

Cell Death Discovery
Nerve injury-induced protein 1 (NINJ1) is a multifunctional membrane protein historically studied for its roles in nerve regeneration and cell adhesion.
Shijun Bao, Fengxu Chen, Ziyi Guo, Wen Ding, Fu Gao, Jiaming Guo   +5 more
doaj   +1 more source

Case report: tracheobronchial diverticulum, a potential risk for diving?

Frontiers in Medicine
Tracheobronchial diverticulum (TBD) is an asymptomatic, benign cystic lesion outside the lumen of the trachea and bronchus. This is the first report case of a SCUBA (self contained underwater breathing apparatus) diver diagnosed with TBD, which is a ...
Long Qing, Yan Wang, Meng Zhang, Qinqin Pu, Wanwan Cai, Yaping Pan, Delin Xia   +6 more
doaj   +1 more source

A Computational Approach for Biomimetic Design of Liver‐On‐A‐Chip

Advanced Intelligent Discovery, EarlyView.
A biomimetic liver‐on‐a‐chip with antiparallel perfusion was designed using COMSOL‐guided simulation to replicate hepatic acinus transport. Full‐scale modelling revealed diffusion‐dominated, length‐dependent nutrient gradients and low‐shear conditions.
Zhenxu Yang, Qiankun Yin, Qingxin Liu, Zhejun Xu, Ye Zhang, Christopher Vega‐Sánchez, Xiaochen Liu, Daniele Vigolo, Jiao Jiao Li, Ken‐Tye Yong   +9 more
wiley   +1 more source