Results 11 to 20 of about 149,617 (194)
Innovation in Therapeutics Development at the NCATS [PDF]
Neuropsychopharmacology, 2013 Never before has there been such a sense of urgency to rethink the way in which therapeutics are discovered and developed. Drug development has grown less efficient with every passing year (http://www.phrma.org; Scannell et al, 2012), at the same time as fundamental understanding of human biology in health and disease has exploded.
Christine M, Colvis +1 more
openaire +2 more sources
Predicting liver cytosol stability of small molecules
Journal of Cheminformatics, 2020 Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of ...
Pranav Shah +5 more
doaj +1 more source
A public–private collaboration model for clinical innovation
Clinical and Translational Science, 2022 Launched in May 2012 as part of the New Therapeutic Uses program, the National Center for Advancing Translational Sciences (NCATS)’ National Institutes of Health (NIH)‐Industry Partnerships initiative fostered collaboration between pharmaceutical ...
Craig D. Wegner +2 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2021 Background Limited knowledge and unclear underlying biology of many rare diseases pose significant challenges to patients, clinicians, and scientists. To address these challenges, there is an urgent need to inspire and encourage scientists to propose and
Qian Zhu +8 more
doaj +1 more source
Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. [PDF]
, 2015 Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin ...
Bild, Diane E +14 more
core +1 more source
National Center for Autonomous Technologies (NCAT)
, 2022 The National Center for Autonomous Technologies (NCAT) was formulated through the National Science Foundation’s Advanced Technological Education (NSF ATE) program in 2019. As the first national ATE center in autonomous technologies, NCAT is crafting, adapting, and implementing educational resources to support K-12 educators, and two-year college ...
Beck, Jonathan, Bergee, Anton
openaire +1 more source
Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells
Scientific Reports, 2021 MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4+ T helper cells which are key players in autoimmune diseases.
Anju Singh +13 more
doaj +1 more source
Science-Business eXchange, 2014 Comments from Christopher Austin, director of the National Center for Advancing Translational Sciences, on how the center is delivering on its promise to overcome roadblocks and accelerate the translational process.
openaire +1 more source
Journal of Biomedical Semantics, 2020 Background The Genetic and Rare Diseases (GARD) Information Center was established by the National Institutes of Health (NIH) to provide freely accessible consumer health information on over 6500 genetic and rare diseases.
Qian Zhu +5 more
doaj +1 more source
Genetic modifiers of ambulation in the cooperative international Neuromuscular Research Group Duchenne natural history study [PDF]
, 2015 OBJECTIVE: We studied the effects of LTBP4 and SPP1 polymorphisms on age at loss of ambulation (LoA) in a multiethnic Duchenne muscular dystrophy (DMD) cohort.
Andreone, Luz +13 more
core +1 more source