Results 21 to 30 of about 149,617 (194)

Exploring NCATS In-House Biomedical Data for Evidence-based Drug Repurposing

PLOS ONE, 2023
AbstractDrug repurposing is a strategy for identifying new uses of approved or investigational drugs that are outside the scope of the original medical indication. Even though many repurposed drugs have been found serendipitously in the past, the increasing availability of large volumes of biomedical data has enabled more systemic, data-driven ...
Fang Liu, Andrew Patt, Chloe Chen, Ruili Huang, Yanji Xu, Ewy A. Mathé, Qian Zhu   +6 more
openaire   +5 more sources

Precision information extraction for rare disease epidemiology at scale

Journal of Translational Medicine, 2023
Background The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated data. Epidemiologic Information (EI)
William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu, Qian Zhu   +9 more
doaj   +1 more source

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury

Redox Biology, 2023
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes.
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin   +20 more
doaj   +1 more source

The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]

, 2018
Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey, Kumar, Parvesh, Reiber, Carl   +2 more
core   +2 more sources

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

Communications Biology, 2023
3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating functional neural spheroids by cell-aggregation of differentiated human induced pluripotent ...
Caroline E. Strong, Jiajing Zhang, Martin Carrasco, Srikanya Kundu, Molly Boutin, Harshad D. Vishwasrao, Jiamin Liu, Angelica Medina, Yu-Chi Chen, Kelli Wilson, Emily M. Lee, Marc Ferrer   +11 more
doaj   +1 more source

Electrical Discharges in Oil-Lubricated Rolling Contacts and Their Detection Using Electrostatic Sensing Technique

Sensors, 2022
The reliability of rolling element bearings has been substantially undermined by the presence of parasitic and stray currents. Electrical discharges can occur between the raceway and the rolling elements and it has been previously shown that these ...
Kamran Esmaeili, Ling Wang, Terry J. Harvey, Neil M. White, Walter Holweger   +4 more
doaj   +1 more source

Effects of dietary protein and fiber at breakfast on appetite, ad libitum energy intake at lunch, and neural responses to visual food stimuli in overweight adults [PDF]

, 2016
Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known.
Amankwaah, Akua F., Campbell, Wayne W., Chen, Ningning, Cornier, Marc-Andre, Kareken, David A., McCrory, Megan A., Sayer, R. Drew, Talavage, Thomas M., Tamer, Gregory G., Tregellas, Jason R., Wright, Amy J.   +10 more
core   +3 more sources

From scientific discovery to treatments for rare diseases – the view from the National Center for Advancing Translational Sciences – Office of Rare Diseases Research

Orphanet Journal of Rare Diseases, 2018
We now live in a time of unprecedented opportunities to turn scientific discoveries into better treatments for the estimated 30 million people in the US living with rare diseases.
Petra Kaufmann, Anne R. Pariser, Christopher Austin   +2 more
doaj   +1 more source

Psychometric Properties of the Altarum Consumer Engagement (ACE) Measure of Activation in Patients with Prediabetes. [PDF]

, 2020
BackgroundPatient activation is associated with better outcomes in chronic conditions.ObjectiveWe evaluated the psychometric properties of the 12-item Altarum Consumer Engagement™ Measure (ACE-12) in patients with prediabetes.ParticipantsACE-12 was ...
Castellon-Lopez, Yelba, Duru, O Kenrik, Grotts, Jonathan, Hays, Ron D, Mangione, Carol M, Moin, Tannaz, Moreno, Gerardo, Norris, Keith C, Skrine Jeffers, Kia   +8 more
core   +3 more sources

Disruptive Strategies for Removing Drug Discovery Bottlenecks [PDF]

, 2012
Drug Discovery is shifting focus from the industry to outside partners and in the process creating new bottlenecks, suggesting the need for a more disruptive overhaul.
Antony Williams, Chris Waller, Mary Bradley, Sean Ekins, Sean Ekins   +4 more
core   +2 more sources