Results 121 to 130 of about 25,091 (203)
Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik +44 more
wiley +1 more source
Future perspectives: Moving towards NCL treatments
, 2015 Clinicians, basic researchers, representatives from pharma and families from around the world met in Cordoba, Argentina in October, 2014 to discuss recent research progress at the 14th International Congress on Neuronal Ceroid Lipofuscinoses (NCLs ...
Kohan, Romina +2 more
core +1 more source
Liver International, Volume 46, Issue 6, June 2026.ABSTRACT Background and Aims An estimated 270 000 people in the UK live with hepatitis B infection, the leading global cause of liver cancer. In 2022, opt‐out hepatitis B testing was introduced in emergency departments (ED) in London. We conducted a 2‐year multicentre evaluation of this programme across seven sites.
Jennifer J. Plunkett +15 more
wiley +1 more source
The Turkish Journal of Pediatrics, 2004 Neuronal ceroid lipofuscinosis (NCL) is one of the most common progressive neurodegenerative diseases seen in childhood. NCL is inherited as autosomal recessive trait, and is characterized by the accumulation of 'ceroid lipofuscin' in neuronal and
Meral Topçu +10 more
doaj
, 2015 The neuronal ceroid lipofuscinoses, collectively called NCLs, are rare and fatal lysosomal storage diseases that mainly affect children. Due to the fact that NCLs are both rare and heterogeneous (mutations in thirteen different genes) significant gaps ...
van der Putten, Herman, Stehr, Frank
core +1 more source
Pathology International, Volume 76, Issue 6, June 2026.Tumor immune microenvironment (TME) is an important pathogenic component in cancer, and a therapeutic target. To examine the role of the TME, especially cancer‐ associated fibroblasts (CAFs) in oral squamous cell carcinoma (SCC), a retrospective cohort study of 684 patients with surgically resected tissues was performed. Immunohistochemical analysis of
Yuuki Ishii +7 more
wiley +1 more source
The MYC/TXNIP axis mediates NCL-Suppressed CD8+T cell immune response in lung adenocarcinoma
Molecular MedicineBackground Lung adenocarcinoma is a deadly malignancy with immune evasion playing a key role in tumor progression. Glucose metabolism is crucial for T cell function, and the nucleolar protein NCL may influence T cell glucose metabolism.
Dan Xiao +5 more
doaj +1 more source
NCL Disorders: Frequent Causes of Childhood Dementia
, 2013 How to Cite This Article: Schulz A, Kohlschütter A. NCL Disorders: Frequent Causes of Childhood Dementia. Iran J Child Neurol. 2013 Winter;7(1):1-8.AbstractDementia in children or young adults is most frequently caused by neuronal ceroidlipofuscinoses (
SCHULZ, Angela, KOHLSCHÃœTTER, Alfried
core +1 more source
Physiological Reports, Volume 14, Issue 11, June 2026.Abstract The cross‐sectional Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) examined effects of athletic exercise and age on endomysium content in human soleus muscle. Forty‐three clinically healthy male participants were grouped into young (20–35 years) nonphysically active controls (n = 12), young power ...
Christoph S. Clemen +6 more
wiley +1 more source
, 2016 Transfections and infections were carried out as described in the previous experiment. In addition to transfections with siRNA constructs, cells were transfected with pEGFP-NCL or pEGFP-C1 vector followed by virus infection.
Shobha Broor (30272) +2 more
core +1 more source