Results 111 to 120 of about 599,165 (331)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Inconsistencies in Simple Thermal Model Results for Near-Earth Asteroids between Infrared Telescope Facility SpeX and NEOWISE Data

open access: yesThe Planetary Science Journal
Understanding the properties of near-Earth asteroids (NEAs) is key for many aspects of planetary science, particularly planetary defense. Our current knowledge of NEA sizes and regolith properties is heavily dependent on simple thermal models.
Samuel A. Myers   +6 more
doaj   +1 more source

The flux of small asteroids near the Earth [PDF]

open access: yes
Fifteen new EA's (Earth approachers) have been discovered since September, among them the smallest asteroids on record: 1990 UN, 1991 BA, and 1991 JR, which are in the 10 to 100 m size range (Scotti et al. 1991b).
Rabinowitz, David L.
core   +1 more source

Robotic and Human Exploration of Near-Earth Objects [PDF]

open access: yes, 2011
U.S. President Obama stated on April 15, 2010 that the next goal for human spaceflight will be to send human beings to a near-Earth asteroid by 2025. Given this direction from the White House, NASA has been involved in studying various strategies for ...
Abell, Paul
core   +1 more source

Near-Earth object 2012XJ112 as a source of bright bolides of achondritic nature [PDF]

open access: bronze, 2014
J. M. Madiedo   +8 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Surface Heterogeneity, Physical, and Shape Model of Near-Earth Asteroid (52768) 1998 OR2

open access: yesThe Planetary Science Journal
On 2020 April 29, the near-Earth object (52768) 1998 OR2 experienced a close approach to Earth at a distance of 16.4 lunar distances (LD). 1998 OR2 is a potentially hazardous asteroid of absolute magnitude H = 16.04 that can currently come as close to ...
Maxime Devogèle   +39 more
doaj   +1 more source

Interception and deviation of near Earth objects via solar collector strategy [PDF]

open access: yes, 2008
A solution to the asteroid deviation problem via a low-thrust strategy is proposed. This formulation makes use of the proximal motion equations and a semi-analytical solution of the Gauss planetary equations.
Colombo, Camilla   +2 more
core   +1 more source

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