Results 131 to 140 of about 599,165 (331)
Near-Infrared Polarimetric Study of Near-Earth Object 252P/LINEAR: An Implication of Scattered Light from the Evolved Dust Particles [PDF]
, 2019 Yuna G. Kwon
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Open Astronomy, 2018 In this paper we retrace the course of near-Earth astronomy from its beginnings.We emphasize the problem of space debris, which has arisen somewhat unexpectedly, and only keeps on growing and growing.We also cast a glance over the conferences, held by ...
Rykhlova Lidiya, Bakanas Elena
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Discovery of near-Earth asteroids by CCD scanning [PDF]
The found near-Earth asteroid are different objects with peculiar orbits. With the new technique of CCD scanning we entered the domain of the smallest, the fastest, and the closest near-Earth asteroids.
Gehrels, Tom +4 more
core +1 more source
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
17. The Issues of Space Debris and Near-Earth Objects at the United Nations [PDF]
, 1998 H. J. Haubold
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FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui +3 more
wiley +1 more source
NEOMOD 3: The debiased size distribution of Near Earth Objects [PDF]
Icarus (New York, N.Y. 1962)D. Nesvorný +11 more
semanticscholar +1 more source
Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein
FEBS Open Bio, EarlyView.This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley +1 more source