Results 131 to 140 of about 1,827,561 (316)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Achieving Representative Faultloads in Software Fault Injection

, 2011
Given the complexity of modern software systems and its pervasiveness in many aspects of our lives, software faults (i.e., bugs) are a dangerous threat.
Natella, Roberto
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Evaluating the impact of superconducting fault current limiters on distribution network protection schemes

, 2011
Rising fault levels are becoming increasingly problematic in the UK distribution network, with large sections of the network operating near to its designed fault level capability.
Burt, Graeme M, Emhemed, Abdullah, Kincaid, Jennifer, Abdulhadi, Ibrahim   +3 more
core  

Least order fault and model detection using multi-models

, 2009
Multi-model based fault detection is often a viable alternative to various multi-model based state estimation techniques using banks of Kalman filters.
A. Varga, Varga, Andreas
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Unzipping of the Conjugate Fault System During the 2024 Mw7.4 Hualien Earthquake

Geophysical Research Letters
On 2 April 2024, a Mw7.4 earthquake struck Taiwan's eastern coast near Hualien City. The fault responsible for the mainshock remained under debate due to the region's complex plate boundary system and intricate fault interactions.
Liuwei Xu, Lingsen Meng, Wenbin Xu, Yen‐Yu Lin, Jianghui Geng, Saeed Mohanna, Grant Kawamoto   +6 more
doaj   +1 more source

Coseismic Deformation Obtained by Various Technical Methods and Its Constraint Ability to Slip Models of Maduo Earthquake

Remote Sensing
The coseismic deformation field on both sides of the fault, especially the distribution and change characteristics of near-field deformation, not only provides important constraints for the fine inversion of the slip distribution model but also serves as
Yujing Song, Chunyan Qu, Chao Ma, Xinjian Shan, Guohong Zhang, Han Chen, Donglin Wu   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Fracture characteristics from two reactivated basement fault zones: examples from Norway and Shetland [PDF]

, 2001
Detailed analyses of fracture attributes developed in basement rocks associated with two, crustal-scale faults, have enabled the characteristics and evolution of the fracture system geometry to be documented quantitatively.
Sleight, Janine Michelle
core