Results 111 to 120 of about 3,570,160 (355)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Transient response of bridge piers under eccentric impact of near-fault earthquake. [PDF]

Sci Rep, 2022
Wang Z, Zeng Q, Du Y, An W.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Unzipping of the Conjugate Fault System During the 2024 Mw7.4 Hualien Earthquake

Geophysical Research Letters
On 2 April 2024, a Mw7.4 earthquake struck Taiwan's eastern coast near Hualien City. The fault responsible for the mainshock remained under debate due to the region's complex plate boundary system and intricate fault interactions.
Liuwei Xu, Lingsen Meng, Wenbin Xu, Yen‐Yu Lin, Jianghui Geng, Saeed Mohanna, Grant Kawamoto   +6 more
doaj   +1 more source

Near-Fault Tilted Deformation of Buildings Associated with Coseismic Surface Ruptures in the Shenxigou Section, 2008 Mw 7.9 Wenchuan Earthquake, Eastern Tibet [PDF]

Lithosphere
The coseismic surface ruptures associated with large earthquakes contribute to severe damage to near-fault buildings through fault deformation. However, previous studies simplified geological conditions and were based mainly on numerical and physical ...
Hao Xue, Hu Wang, Lin Deng, Kaijin Li, Jinlong Cai   +4 more
doaj   +1 more source

Influence of source directivity and site effects of 2003 Tokachi-oki earthquake on the generation of high PGA in the near-fault zones. [PDF]

Sci Rep, 2022
Pavlenko OV.
europepmc   +1 more source

Study on characteristic parameters of near-fault response spectrum

IOP Conference Series: Materials Science and Engineering, 2018
883 vertical earthquake records within the fault distance of 100 km were selected to study that whether the vertical design response spectrum characteristic parameter should be also used for the seismic design of engineering structure in near-fault region.
Jiale Li, Hongjing Li, Guangjun Sun
openaire   +1 more source

Seismic protection of cable-stayed bridges applying fluid viscous dampers [PDF]

, 2009
The present work constitutes an approach to the seismic protection of cable-stayed bridges including the incorporation of fluid viscous dampers as additional energy dissipation devices.
Aparicio Bengoechea, Ángel Carlos, Valdebenito, Galo   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Coseismic Deformation Obtained by Various Technical Methods and Its Constraint Ability to Slip Models of Maduo Earthquake

Remote Sensing
The coseismic deformation field on both sides of the fault, especially the distribution and change characteristics of near-field deformation, not only provides important constraints for the fine inversion of the slip distribution model but also serves as
Yujing Song, Chunyan Qu, Chao Ma, Xinjian Shan, Guohong Zhang, Han Chen, Donglin Wu   +6 more
doaj   +1 more source