Results 101 to 110 of about 3,570,160 (355)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effects of Off‐Fault Inelasticity on Near‐Fault Directivity Pulses

Journal of Geophysical Research: Solid Earth, 2019
AbstractNear‐fault motion is often dominated by long‐period, pulse‐like particle velocities with fault‐normal polarization that, when enhanced by directivity, may strongly excite middle‐ to high‐rise structures. We assess the extent to which plastic yielding may affect amplitude, frequency content, and distance scaling of near‐fault directivity pulses.
Yongfei Wang, Steven M. Day
openaire   +2 more sources

Using Lidar Data to Analyse Sinkhole Characteristics Relevant for Understory Vegetation under Forest Cover\u2014Case Study of a High Karst Area in the Dinaric Mountains [PDF]

, 2015
In this article, we investigate the potential for detection and characterization of sinkholes under dense forest cover by using airborne laser scanning data.
Igor, Dakskobler, Irena, Bertoncelj, Lado, Kutnar, Milan, Kobal, Pirotti, Francesco   +4 more
core   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The effect of the number of response cycles on the behaviour of reinforced concrete elements subject to cyclic loading [PDF]

, 2012
The development of damage in reinforced concrete (RC) structures is a cumulative process. Some damage indices used to quantify damage make use of the number of response cycles as an Engineering Demand Parameter (EDP) relating with damage development ...
Borg, R. C., Rossetto, T., Varum, H.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Discrete Element Modeling of Near-Surface Fault Rupture Evolution Along the Milun Fault in Taiwan

Applied Sciences
Understanding the shallow rupture mechanisms on coseismic faults and assessing the influence of fault area propagation is essential for disaster prevention.
Xiao-Fei Guo, Yosuke Aoki, Jiang-Hai Li
doaj   +1 more source

Investigating Active Deformation in the Northern Longitudinal Valley and City of Hualien in Eastern Taiwan Using Persistent Scatterer and Small-Baseline SAR Interferometry

Terrestrial, Atmospheric and Oceanic Sciences, 2011
Rapid convergence between the Eurasian plate and the Philippine Sea plate in the northern Longitudinal Valley near the city of Hualien in eastern Taiwan has produced prominent fault scarps and large earthquakes (M ¡_ 7).
Jiun-Yee Yen, Chih-Heng Lu, Chung-Pai Chang, Andrew John Hooper, Yo-Ho Chang, Wen-Tzong Liang, Tsui-Yu Chang, Ming-Sheng Lin, Kun-Shan Chen   +8 more
doaj   +1 more source

Seismological analyses of the 2010 March 11, Pichilemu, Chile M_w 7.0 and M_w 6.9 coastal intraplate earthquakes [PDF]

, 2014
On 2010 March 11, a sequence of large, shallow continental crust earthquakes shook central Chile. Two normal faulting events with magnitudes around M_w 7.0 and M_w 6.9 occurred just 15 min apart, located near the town of Pichilemu.
Carrizo, Daniel, Comte, Diana, Hayes, Gavin P., Kanamori, Hiroo, Ruiz, Javier A., Socquet, Anne   +5 more
core