Results 91 to 100 of about 3,570,160 (355)

Introducing Adaptive Incremental Dynamic Analysis: A New Tool for Linking Ground Motion Selection and Structural Response Assessment [PDF]

, 2013
Adaptive Incremental Dynamic Analysis (AIDA) is a novel ground motion selection scheme that adaptively changes the ground motion suites at different ground motion intensity levels to match hazardconsistent properties for structural response assessment ...
Baker, Jack W., Lin, Ting
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Spectral Characterization of Himalayan Near-Fault Ground Motion

Periodica Polytechnica Civil Engineering, 2016
Near-Fault Ground Motion (NFGM) spectral characteristics of three moderate-sized Himalayan earthquakes, viz., the 1986 Dharamsala earthquake (Mw = 5:5), the 1991 Uttarkashi earthquake (Mw = 6:8), and the 1999 Chamoli earthquake (Mw = 6:5) have been studied from the 33 available strong ground motion recordings.
Prabhat Kumar, Ashwani Kumar, Ashok Deota Pandey   +2 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Data-Driven Simulation of Near-Fault Ground Motions Using Stationary Wavelet Transform and Hilbert Analysis

Buildings
Near-fault ground motions exhibit significant characteristics such as velocity pulses, rupture directivity, and strong vertical components, which pose serious threats to structural safety.
Weikun He, Zexin Guo, Chaobin Li, Wei Wang, Biao Wei, Ping Shao, Yongping Zeng   +6 more
doaj   +1 more source

Dissolved noble gases and stable isotopes as tracers of preferential fluid flow along faults in the Lower Rhine Embayment, Germany [PDF]

, 2015
Groundwater in shallow unconsolidated sedimentary aquifers close to the Bornheim fault in the Lower Rhine Embayment (LRE), Germany, has relatively low δ2H and δ18O values in comparison to regional modern groundwater recharge, and 4He concentrations up to
A Mayer, A Schäfer, A Schäfer, AL Flint, B Marty, B Marty, BJ Mailloux, C Cassiat, CAJ Appelo, CM Bethke, D Wiprut, DK Solomon, DL Egholm, DN Dewhurst, E Griesshaber, ER Oxburgh, F Peeters, GC Rawling, H Hager, HA Kemna, J Lippmann, J Lippmann, J Lippmann-Pipke, JC Poole, JN Andrews, JR Fulljames, JT Kulongoski, JT Kulongoski, K. M. Hiscock, L Ma, L. P. Gumm, M Bickle, M Stute, M Stute, MA Chan, MC Castro, MC Castro, MC Castro, MC Geluk, N. Cremer, P. F. Dennis, PA Ziegler, R Kipfer, R Vaikmäe, S. Simon, SJ Roberts, SMV Gilfillan, T Torgersen, T Torgersen, T Torgersen, T Torgersen, T Wiersberg, U Beyerle, V Lavastre, V. F. Bense, VF Bense, VF Bense, VF Bense, VF Bense, VF Bense, W Aeschbach-Hertig, W Boenigk, WP Gardner, Y Sano, YV Dublyansky, Z Zhou   +65 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effect of a Near Fault on the Seismic Response of a Base-Isolated Structure with a Soft Storey

Slovak Journal of Civil Engineering, 2017
This study focuses on the soft-storey behavior of RC structures with lead core rubber bearing (LRB) isolation systems under near and far-fault motions.
Athamnia B., Ounis A., Abdeddaim M.
doaj   +1 more source

Postseismic rebound due to creep of the lower lithosphere and asthenosphere [PDF]

Postseismic surface deformations are attributed to the inelastic flow of the subcrustal regions of the Earth following an earthquake. A multilayer representation of the Earth's rheological properties is used in conjunction with a finite element ...
Cohen, S. C.
core   +1 more source

Simulation of rock salt dissolution and its impact on land subsidence [PDF]

, 2013
Extensive land subsidence can occur due to subsurface dissolution of evaporites such as halite and gypsum. This paper explores techniques to simulate the salt dissolution forming an intrastratal karst, which is embedded in a sequence of carbonates, marls,
Huggenberger, P., Younes, A., Zechner, E., Zidane, A.   +3 more
core   +2 more sources