Results 71 to 80 of about 1,827,561 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Dizhen xuebao为进一步了解近断层地震动的显著竖向特性和速度脉冲特性，基于NGA-West2强地面运动数据库选取1 706组强地震动记录，研究了竖向与水平向加速度峰值比aV/aH的总体分布特征，并探讨了aV/aH随矩震级MW、断层距Rjb、场地类别和断层类型变化的规律。在此基础上，通过Baker脉冲识别方法选取出140组近断层速度脉冲地震动，并提取出每条地震动记录的脉冲周期Tp和速度脉冲峰值PGVp，研究其脉冲参数随矩震级MW和断层距Rjb变化的统计规律及经验模型。结果表明：近断层加速度峰值比aV ...
Shangrong Zhang +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Nonlinear Seismic Responses of Near-Fault Building Clusters Caused by the Fault Rupture
BuildingsAn integrated numerical method is proposed for analyzing the nonlinear seismic response of near-fault building clusters, comprising three algorithms: (1) a structural investigated lump algorithm for elastoplastic dynamic response of structure; (2) a ...
Wei Zhong +4 more
doaj +1 more source
Deep test hole drilled near fault
Eos, Transactions American Geophysical Union, 1980 In an effort to answer troublesome questions about stresses on the San Andreas fault, a team of U.S. Geological Survey (USGS) researchers is compiling data from in situ measurements in the deepest hole ever drilled, for scientific purposes, on or near the San Andreas fault.Headed by Mark Zoback, the team recently finished drilling the 1‐km hole, made ...
openaire +1 more source
Research on Near-Fault Problems in Earthquake Engineering
TELKOMNIKA Indonesian Journal of Electrical Engineering, 2012 The state-of-the-art of near-fault problems in earthquake engineering is comprehensive reviewed. Strong ground motions in the near-fault region exhibit several new characteristics, which cause the attentions of both seismologists and engineers who zealously studied these ground motions during the last two deceases.
openaire +1 more source
Incorporation of fault rock properties into production simulation models [PDF]
, 2005 This thesis has two aims. First, to investigate the importance of incorporating the multiphase flow properties of faults into production simulation models.
Al-Busafi, Bader
core
, 2008 Structural complexity is common at the terminations of earthquake surface ruptures; similar deformation may therefore be expected at the end zones of earthquake ruptures at depth.
Kirkpatrick, J. D. +14 more
core +1 more source
Changes in hot spring temperature and hydrogeology of the Alpine Fault hanging wall, New Zealand, induced by distal South Island earthquakes [PDF]
, 2014 Thermal springs in the Southern Alps, New Zealand, originate through penetration of fluids into a thermal anomaly generated by rapid uplift and exhumation on the Alpine Fault.
Teagle, D.A.H. +9 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source