Results 51 to 60 of about 3,570,160 (355)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Synthetic Ground-Motion Simulation Using a Spatial Stochastic Model with Slip Self-Similarity: Toward Near-Source Ground-Motion Validation

open access: yesTerrestrial, Atmospheric and Oceanic Sciences, 2016
Near-fault ground motion is a key to understanding the seismic hazard along a fault and is challenged by the ground motion prediction equation approach. This paper presents a developed stochastic-slip-scaling source model, a spatial stochastic model with
Ya-Ting Lee   +4 more
doaj   +1 more source

Deep test hole drilled near fault

open access: yesEos, Transactions American Geophysical Union, 1980
In an effort to answer troublesome questions about stresses on the San Andreas fault, a team of U.S. Geological Survey (USGS) researchers is compiling data from in situ measurements in the deepest hole ever drilled, for scientific purposes, on or near the San Andreas fault.Headed by Mark Zoback, the team recently finished drilling the 1‐km hole, made ...
openaire   +1 more source

Finite Fault Source Model for Ground Motion near Fault Zone

open access: yesIABSE Congress Reports, 2022
<p>Ground motion is categorized into near fault zone and across fault zone where impulsive component is included. The impulsive component usually causes larger damage than that by far-fault ground motion. To build a Benchmark model platform for cable-stayed bridges across-fault region for comparative analysis, the paper proposes a way combining ...
Qiu, Yuan   +5 more
openaire   +2 more sources

Buried shallow fault slip from the South Napa earthquake revealed by near-field geodesy. [PDF]

open access: yes, 2017
Earthquake-related fault slip in the upper hundreds of meters of Earths surface has remained largely unstudied because of challenges measuring deformation in the near field of a fault rupture.
Brooks, Benjamin   +14 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Geodetic Observations of Weak Determinism in Rupture Evolution of Large Earthquakes. [PDF]

open access: yes, 2018
The moment evolution of large earthquakes is a subject of fundamental interest to both basic and applied seismology. Specifically, an open problem is when in the rupture process a large earthquake exhibits features dissimilar from those of a lesser ...
Allen, RM   +3 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

近断层地震动加速度峰值比和脉冲特征的统计分析

open access: yesDizhen xuebao
为进一步了解近断层地震动的显著竖向特性和速度脉冲特性,基于NGA-West2强地面运动数据库选取1 706组强地震动记录,研究了竖向与水平向加速度峰值比aV/aH的总体分布特征,并探讨了aV/aH随矩震级MW、断层距Rjb、场地类别和断层类型变化的规律。在此基础上,通过Baker脉冲识别方法选取出140组近断层速度脉冲地震动,并提取出每条地震动记录的脉冲周期Tp和速度脉冲峰值PGVp,研究其脉冲参数随矩震级MW和断层距Rjb变化的统计规律及经验模型。结果表明:近断层加速度峰值比aV ...
Shangrong Zhang   +3 more
doaj   +1 more source

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