Results 121 to 130 of about 3,570,160 (355)

Application of Polynomial Rocking Bearings as Seismic Isolation System on Irregular Bridges

Civil and Environmental Science Journal, 2018
Friction Pendulum System (FPS) is one of the conventional sliding isolators which widely used and effectively proved to reduce seismic hazard in far-fault earthquakes.
Krisna Febrian Anugerahputra, Lee Tzu Ying, Ari Wibowo   +2 more
doaj   +1 more source

Influence of seismic events on shallow geotechnical structures [PDF]

, 2017
This paper deals with a summary of possible seismic loading of shallow geotechnical structures. It is known that seismic loading influences the underground structures much less than the structures on the surface, therefore, it is not usually taken into ...
Kaláb, Zdeněk, Štemon, Pavel
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Near-Fault Response and Loading Protocols of Box Columns in Steel Frames with Self-Centering Braces to Provide Recentering Capability

Advances in Civil Engineering
The main objective of this study was to establish loading protocols for self-centering braced frames (SCBFs) while taking into account the impact of near-fault ground motions.
Yu-Fang Liu, Chung-Che Chou, Chia-Ying Chung, Hao-Che Huang   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Optimal Design and Seismic Performance of Base-Isolated Structures with Varying Heights Equipped with Tuned Inerter Dampers Subjected to Far-Fault and Near-Fault Ground Motions

Applied Sciences
This paper investigates the optimal design of base-isolated structures equipped with tuned inerter dampers (TIDs) subjected to various ground motions. The Clough–Penzien model is employed to simulate the power spectrum of three types of ground motions ...
Yingjie Kang, Zewen Zhang, Zeyu Zhang, Xinyu Zhang, Qingkuan Liu   +4 more
doaj   +1 more source

PEER Testbed Study on a Laboratory Building: Exercising Seismic Performance Assessment [PDF]

, 2005
From 2002 to 2004 (years five and six of a ten-year funding cycle), the PEER Center organized the majority of its research around six testbeds. Two buildings and two bridges, a campus, and a transportation network were selected as case studies to ...
Beck, James L., Chang, Stephanie E., Chaudhuri, Samit Ray, Comerio, Mary C., Falit-Baiamonte, Anthony, Holmes, William T., Hutchinson, Tara, Konstantinidis, Dimitrios, Lee, Tae-Hyung, Makris, Nicos, Mosalam, Khalid, Porter, Keith A., Shaikhutdinov, Rustem, Smith, Ryan, Somerville, Paul, Stallmeyer, John C.   +15 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source