Results 61 to 70 of about 36,590 (291)

Refining the shallow slip deficit [PDF]

open access: yes, 2016
Geodetic slip inversions for three major (M_w > 7) strike-slip earthquakes (1992 Landers, 1999 Hector Mine and 2010 El Mayor–Cucapah) show a 15–60 per cent reduction in slip near the surface (depth < 2 km) relative to the slip at deeper depths (4–6 km ...
Ayoub, François   +7 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

近断层地震动加速度峰值比和脉冲特征的统计分析

open access: yesDizhen xuebao
为进一步了解近断层地震动的显著竖向特性和速度脉冲特性,基于NGA-West2强地面运动数据库选取1 706组强地震动记录,研究了竖向与水平向加速度峰值比aV/aH的总体分布特征,并探讨了aV/aH随矩震级MW、断层距Rjb、场地类别和断层类型变化的规律。在此基础上,通过Baker脉冲识别方法选取出140组近断层速度脉冲地震动,并提取出每条地震动记录的脉冲周期Tp和速度脉冲峰值PGVp,研究其脉冲参数随矩震级MW和断层距Rjb变化的统计规律及经验模型。结果表明:近断层加速度峰值比aV ...
Shangrong Zhang   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Comparison between the Effects of Near- and Far-Fault Ground Motions on the Seismic Response of a Soil-Pile-Structure System [PDF]

open access: yesJournal of Structural and Construction Engineering, 2016
Ground motions recorded in near-fault sites, where the rupture propagates toward the site, are significantly different from those observed in far-fault regions.
Saeed Abbasi Karafshani   +2 more
doaj  

Effect of near-fault ground motion with pulse signal on dynamic response of dam-reservoir-foundation systems

open access: yesGrađevinar, 2023
This paper aimed to determine the effects of a pulse signal of near-fault ground motion on the dynamic response of gravity dams, including dam-reservoir-foundation interaction, using different reservoir modelling approaches such as Westergaard, Lagrange,
Ahmet Can Altunisik   +2 more
doaj   +1 more source

Tsunami generation by dynamic displacement of sea bed due to dip-slip faulting [PDF]

open access: yes, 2008
In classical tsunami-generation techniques, one neglects the dynamic sea bed displacement resulting from fracturing of a seismic fault. The present study takes into account these dynamic effects.
Benkhaldoun   +24 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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