Results 91 to 100 of about 574,698 (334)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Scanning Probe Microscopy as a Tool for Investigation of Biomaterials

open access: yesAdvances in Electrical and Electronic Engineering, 2012
Super-microscopic techniques like scanning tunnelling microscopy, atomic force microscopy or scanning near-field optical microscopy allows investigate micro- and/or nano-scale surfaces and structures.
Veronika Novotna   +3 more
doaj   +1 more source

Photon-induced near-field electron microscopy (PINEM): theoretical and experimental [PDF]

open access: yes, 2010
Electron imaging in space and time is achieved in microscopy with timed (near relativistic) electron packets of picometer wavelength coincident with light pulses of femtosecond duration.
Lin, Milo   +2 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Improved Point Dipole Model for Subwavelength Resolution Scattering Near-Field Optical Microscopy (SNOM)

open access: yesInternational Journal of Antennas and Propagation, 2020
High-resolution microscopy technique is of significant importance for studying nanomaterials. It is necessary to understand the near-field interaction between the probe and substrate materials in order to get the fine structure of the nanomaterial in the
Guizhen Lu   +4 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Fluorescent oxide nanoparticles adapted to active tips for near-field optics

open access: yes, 2008
We present a new kind of fluorescent oxide nanoparticles with properties well suited to active-tip based near-field optics. These particles with an average diameter in the range 5-10 nm are produced by Low Energy Cluster Beam Deposition (LECBD) from a ...
A Cuche   +16 more
core   +3 more sources

Near-Field Plasmon-Resonance Scanning Microscopy [PDF]

open access: yesMicroscopy Today, 1995
Abstract In the past few years the field of near-field scanning optical microscopy (NSOM) has developed rapidly with applications spanning all the physical sciences. A key goal of this form of microscopy is to obtain resolution at levels well beyond those possible with the usual far-field optics. In contrast to far-field optics, which is
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Tunable-Focusing of Surface Plasmon Polaritons With a Slightly Irregular Line of Nanofootprints

open access: yesIEEE Photonics Journal, 2018
Tunable surface plasmon polariton launchers are highly demanded in various applications of nanophotonics for achieving controllable plasmonic signals coupling and multiplexing. Here, a tunable-focusing device with simplified structure is suggested.
Mingqian Zhang, Lin Sun, Jia Wang
doaj   +1 more source

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