Results 81 to 90 of about 10,023,443 (259)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Photocurrent near-field microscopy of Schottky barriers
We used a combination of internal photoemission and of near-field optical microscopy (SNOM) to study the lateral Variations in solid interface properties such as energy barriers and electron-hole recombination.
Spajer, M. +10 more
core +1 more source
Near-field imaging beyond the probe aperture limit
, 2019 Near-field scanning optical microscopy has been an indispensable tool for designing, characterizing and understanding the functionalities of diverse nanoscale photonic devices. As the advances in fabrication technology have driven the devices smaller and
Joonmo Ahn (17505426) +9 more
core +1 more source
Sub-wavelength focusing of high intensities in microfibre tips
Sub-wavelength efficient intensity confinement has been demonstrated in nanostructured optical microfibre tips. Focus Ion Beam (FIB) milling was used to nanostructure gold-coated optical microfibre tips and form apertures at the apex.
Ding, M. +9 more
core +1 more source
Beilstein Journal of Nanotechnology, 2013 Both fluorescence imaging and atomic force microscopy (AFM) are highly versatile and extensively used in applications ranging from nanotechnology to life sciences. In fluorescence microscopy luminescent dyes serve as position markers.
Alexander Harder +7 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Near-Field Probing of Microwave Oscillators with Josephson Microscopy
Voltage-controlled oscillators, serving as fundamental components in semiconductor chips, find extensive applications in diverse modules such as phase-locked loops, clock generators, and frequency synthesizers within high-frequency integrated circuits ...
Jingjing Lv (5276036) +11 more
core +1 more source
New methods to reduce leakage errors in planar near-field measurements [PDF]
, 2011 This paper describes two methods to cancel the effect of two kinds of leakage signals which may be presented when an antenna is measured in a planar near-field range.
Cano Facila, Francisco Jose +2 more
core
Optical Near-Field Harmonic Demodulation in Apertureless Microscopy
, 2001 Spatial derivatives of the optical fields scattered by a surface can be investigated by apertureless near-field optical microscopy by modulating sinusoidally the probe to sample distance and detecting the optical signal at the first and higher harmonics.
N. MAGHELLI +5 more
core +1 more source