Results 61 to 70 of about 652,820 (300)

Miniature modular microwave end-to-end receiver [PDF]

, 1993
An end-to-end microwave receiver system contained in a single miniature hybrid package mounted on a single heatsink is presented. It includes an input end connected to a microwave receiver antenna and an output end which produces a digital count ...
Cooley, Thomas W., Janssen, Michael A., Parks, Gary S., Sukamto, Lin M.   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Torsional Strengthening of RC Beams with Continuous Spiral Near-Surface Mounted Steel Wire Rope

International Journal of Concrete Structures and Materials, 2020
The strength of reinforced concrete members can be enhanced using externally bonded reinforcement (EBR) and near surface mounted (NSM) methods. However, small number of studies has adopted the NSM method for torsional strengthening. To date, no study has
Nasih Habeeb Askandar, Abdulkareem Darweesh Mahmood   +1 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Near surface mounted CFRP-based technique for the strengthening of concrete structures [PDF]

, 2004
To assess the effectiveness of the Near Surface Mounted (NSM) strengthening technique, an experimental program was carried out involving reinforced concrete (RC) columns and beams. In columns failing in bending the present work shows that the failure
Barros, Joaquim A. O., Dias, Salvador J. E., Ferreira, Débora R. S. M., Fortes, Adriano, Sena-Cruz, José   +4 more
core   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

In plane Shear Strengthening of Clay Masonry Walls with Opening

Sulaimani Journal for Engineering Sciences, 2020
In this paper, results of testing eight clay brick wall specimens are presented. Seven of the walls contained opening and one wall without opening. The walls were tested under constant uniformly distributed vertical load and gradually increased lateral ...
Sarwat Hassan Ahmed, Muhammad Raouf Abdulkadir   +1 more
doaj   +1 more source

Near-surface Mounted Technology in Strengthening Reinforced Concrete Beam

International Journal of Sustainable Construction Engineering and Technology
Structural strengthening is essential in civil engineering to ensure the integrity, safety, and longevity of various types of structures. Effective strengthening is required to solve these issues and lengthen the service life of structures as they naturally deteriorate with time. Hence, the use of various strengthening techniques
Muhammad Adam Syahmi Dazulhisham, Muhammad Arif Ikmal Abdul Halim, Lyn Dee Goh   +2 more
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Performance of Rubberized RC Beams Flexural-Strengthened Using Near-Surface Mounted Systems

International Journal of Concrete Structures and Materials
This research investigates the flexural performance of strengthened rubberized concrete beams via bottom, side, and hybrid near-surface mounted (NSM) approaches using GFRP/steel rebars. Eleven strengthened specimens, alongside one control, were subjected
Mohamed Emara, Abdulrahman H. Mostafa, Heba A. Mohamed, Mahmoud Zaghlal   +3 more
doaj   +1 more source