Results 91 to 100 of about 102,036 (238)

Convergence, Sticking and Escape: Stochastic Dynamics Near Critical Points in SGD

CoRR
We study the convergence properties and escape dynamics of Stochastic Gradient Descent (SGD) in one-dimensional landscapes, separately considering infinite- and finite-variance noise. Our main focus is to identify the time scales on which SGD reliably moves from an initial point to the local minimum in the same ''basin''.
Dmitry Dudukalov, Artem Logachov, Vladimir Lotov, Timofei Prasolov, Evgeny Prokopenko, Anton Tarasenko   +5 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Effect of Yogic Ocular Exercises on Convergence Insufficiency

Liaquat Medical Research Journal
Objective: To assess the effect of yogic ocular exercises on convergence insufficiency Methodology: A quasi-experimental study was conducted at the University of Lahore Teaching Hospital from July -August 2025.
Sharmeen Shahid, Muhammad Haris, Zainab Shafqat, Faiza Ejaz   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Home vision therapy and prism prescription in presbyopic persons with convergence insufficiency: study protocol for a randomized controlled trial

BMC Ophthalmology
Background Convergence insufficiency is a common issue in the field of binocular vision. Various treatment options have been suggested for managing this condition, but their efficacy in individuals with presbyopia remains unclear.
Saeid Abdi, Haleh Kangari, Saeed Rahmani, Alireza Akbarzadeh Baghban, Zahra Kamary Rad   +4 more
doaj   +1 more source

Orthoptic Treatment After Strabismus Surgery in Child Intermittent Divergent Strabismus

Children
Purpose: To evaluate short-term motor and sensory–motor outcomes following postoperative OT in children with IXT after strabismus surgery. Methods: This prospective before–after observational study included children with IXT who underwent bilateral ...
Pedro Lino, Pedro Vargues de Aguiar, João Paulo Cunha   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

The Interaction between Vergence and Accommodation Cues in the Assessment of Fusional Vergence Range

Life
Fusional vergence range tests are commonly used in optometric practice. The aim of this study was to investigate the possible contribution of CA/C, AC/A, and proximal cues (PCT) to the magnitude and presence of blur and recovery during the measurement of
Marc Argilés, Genis Cardona
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source