Results 101 to 110 of about 807,286 (280)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Accommodative Ability in Prepresbyopic Diabetic Patients [PDF]

Patient Safety and Quality Improvement Journal, 2015
Introduction: To compare various accommodative parameters in prepresbyopic diabetic patients with age-matched healthy individuals. Materials and Methods: Study populationconsisted of 32 younger-onset diabetic patients (30-40 years of age) and 28 age ...
Mohammad Etezad Razavi, Mohammad Sharifi, Majid Abrishami, Mojtaba Zaker Abbasi   +3 more
doaj  

Catalyst Acceleration for Gradient-Based Non-Convex Optimization [PDF]

, 2017
We introduce a generic scheme to solve nonconvex optimization problems using gradient-based algorithms originally designed for minimizing convex functions.
Drusvyatskiy, Dmitriy, Harchaoui, Zaid, Lin, Hongzhou, Mairal, Julien, Paquette, Courtney   +4 more
core   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Effectiveness of binocular vision therapy in managing patients with intermittent exotropia

Indian Journal of Ophthalmology
Purpose: Evaluating the effect of binocular vision training (BVT) on Newcastle Control Score (NCS)-Home, near stereopsis and convergence amplitudes in intermittent exotropia (IXT). Design: Retrospective observational study. Methods: 30 subjects diagnosed
Affan Ashfaque Ahmed Ansari, Pradeep Sharma, Erum W Khateeb, Faiza Bhombal, Shruti Lad, Varsha Jain, Areeba Usmani, Antariksh Jain, Md Oliullah Abdal   +8 more
doaj   +1 more source

Semi-analytical approximation of the normal derivative of the heat simple layer potential near the boundary of a two-dimensional domain [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
A semi-analytical approximation of the normal derivative of the simple layer heat potential near the boundary of a two-dimensional domain with $C^{5} $ smoothness is proposed.
Ivanov, Dmitrii Yurievich
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Conjunctival erosion after glaucoma drainage device surgery: A feasible option

Indian Journal of Ophthalmology, 2013
Glaucoma drainage devices (GDDs) have been used in the management of complicated glaucomas. GDDs are associated with various complications such as tube migration, tube or plate exposure or extrusion, ocular motility disturbance and infection.
Suneeta Dubey, Baswati Prasanth, Manisha C Acharya, Ritesh Narula   +3 more
doaj   +1 more source