Results 61 to 70 of about 1,231,300 (341)

Flexural Capacity Prediction of RC Beams Strengthened in Terms of NSM System Using Soft Computing [PDF]

Journal of Soft Computing in Civil Engineering
In recent years, there has been a notable increase in the application of near-surface mounted fiber-reinforced polymer (FRP) reinforcement in reinforced concrete structures.
Amin Raeisi, Mohammad Kazem Sharbatdar, Hosein Naderpour, Pouyan Fakharian   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Parametric investigation of flexural performance of concrete prisms retrofitted with near-surface mounted FRP bars

Composites Part C: Open Access, 2023
This study investigates the impact of flexural retrofitting on the load-bearing capacity, ductility and failure modes of concrete prisms using the NSM-FRP technique, considering four design parameters.
Mohammad Al-Zu'bi, Mizi Fan, Lorna Anguilano   +2 more
doaj   +1 more source

Punching Shear Resistance of Flat Slabs Strengthened with Near Surface–Mounted CFRP Bars

, 2021
This paper presents the effectiveness of strengthening slab–column connections against punching shear failure with near surface–mounted (NSM) carbon fiber–reinforced polymer (CFRP) bars.
Hikmatullah Akhundzada, T. Donchev, D. Petkova   +2 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental and numerical study of bond between masonry and near-surface mounted steel bars

Case Studies in Construction Materials, 2020
This addresses the bond between masonry and near surface mounted steel bars through experimental and numerical investigation. In the experimental program, 12 masonry prisms were prepared from commercial clay bricks and were strengthened using NSM steel ...
Tarek S. El-Salakawy, Gehan A. Hamdy, Mohamed O.R. Al-Hariri, Samar I. Mubarak   +3 more
doaj   +1 more source

EFFECT OF NEAR-SURFACE MOUNTED BARS ON THE STRUCTURAL BEHAVIOR OF ONE-WAY RC SLAB

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ, 2021
The present research paper deals with the finite element modelling of continuous one-way reinforced concrete (RC) slabs strengthened by near surface mounted (NSM) bars under static loads.
Hayder H. Kamonna, Douaa J. Abd Al-Sada
doaj   +1 more source

Application of near surface mounted (NSM) strengthening technique to traditional timber frame walls [PDF]

, 2015
Timber frame buildings are well known as an efficient seismic resistant structure popular all over the world not only due to their seismic performance, but also to their low cost and the strength they offer.
Jorge, Marco António Peixoto, Poletti, Elisa, Vasconcelos, Graça   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source