Results 121 to 130 of about 7,318 (296)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Matrix nearness problems in data mining [PDF]

open access: yes, 2007
textThis thesis addresses some fundamental problems in data mining and machine learning that may be cast as matrix nearness problems. Some exam- ples of well-known nearness problems are: low-rank approximations, sparse approximations, clustering, co ...
Sra, Suvrit, 1976-
core  

Computational structure in three-valued nearness relations

open access: yes, 2001
. The development of cognitively plausible models of human spatial reasoning may ultimately result in computational systems that are better equipped to meet human needs.
Matt Duckham, Michael Worboys
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Connection Properties in Nearness Spaces

open access: yes, 1985
We prove that a topological space X has a locally connected regular T1, extension if and only if X is the underlying topological space of a nearness space Y which is concrete, regular and uniformly locally uniformly connected.
H. L. Bentley, R. G. Ori, D. Baboolal
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

The Metric Nearness Problem

open access: yes, 2006
. Metric nearness refers to the problem of optimally restoring metric properties to distance measurements that happen to be non-metric due to measurement errors or otherwise.
Inderjit S. Dhillon   +4 more
core  

Symmetrical extensions and generalized nearness

open access: yes, 2003
A common concept of supertopologies and nearness, called supernearness, is considered. Moreover, we will characterize those supernear spaces which can be extended to topological ones in the symmetrical ...
Leseberg, Dieter
core   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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