Results 41 to 50 of about 8,970 (252)

Samuel compactification and uniform coreflection of nearness $\sigma$-frames

open access: yes, 2006
summary:We introduce the structure of a nearness on a $\sigma $-frame and construct the coreflection of the category ${\mathbf N\sigma Frm}$ of nearness $\sigma $-frames to the category ${\mathbf KReg\sigma Frm}$ of compact regular $\sigma $-frames. This
Naidoo, Inderasan
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Suartėjimas: koegzistencinės analizės patirtis

open access: yesProblemos, 2014
The essay carries out the primary phenomenological explication of rapprochement (drawing nearer) as a fundamental mode of Being-with-one-another. Proceeding from the existential interpretation of space given in Heidegger's Being and Time the author shows
Tatiana Shchyttsova
doaj   +1 more source

Investigating the relationship between Dwelling and Calling in Heidegger`s Views. [PDF]

open access: yesحکمت و فلسفه, 2010
According to the modern thought, the essence of human is his subjectivity and the world is mere extension and object of study. The result of this manner of thinking is the separation of the world and human being and alienation of human being from the ...
mohammad javad safian   +1 more
doaj   +1 more source

Bi-directional nearness in a network by AHP (Analytic Hierarchy Process) and ANP (Analytic Network Process) [PDF]

open access: yes, 2000
In this paper we study bi-directional nearness in a network based on AHP (Analytic Hierarchy Process) and ANP (Analytic Network Process). Usually we use forward (one-dimensional) direction nearness based on Euclidean distance.
Kazutomo Nishizawa, Nishizawa, Kazutomo
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Making Distance Visible: Assembling Nearness in an Online Distance Learning Programme

open access: yesInternational Review of Research in Open and Distributed Learning, 2013
Online distance learners are in a particularly complex relationship with the educational institutions they belong to (Bayne, Gallagher, & Lamb, 2012). For part-time distance students, arrivals and departures can be multiple and invisible as students take
Jen Ross   +2 more
doaj   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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