Results 41 to 50 of about 4,285 (257)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Tema nou-testamentară a apropierii și întârzierii parusiei în Evul Mediu
TheoRhēma, 2018 The article surveys the medieval reception of the NT message that the second coming of Jesus or the end of the world is near and how Christians during this time span coped with the delay of the Parousia.
Laurențiu Florentin Moț
doaj +2 more sources
Journal of Applied Mathematics, 2012 To avoid the false results of deterministic identification methods induced by uncertainties, a fuzzy nearness-based method is proposed for the damage identification of bridge.
Hanbing Liu +3 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Properties and Indicators of Ethical Propositions in Quran and Hadith [PDF]
اخلاق وحیانی, 2016 In Islamic ethical propositions, ethical orders signify the desirability of their subjects and their positive or negative relation to happiness, but in the ethical propositions included in Quran and Hadith there is hardly any instance of these concepts ...
Mohammad Ja’far Sadri, Mahmud Rajabi
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Acts 17:27 - "that they might feel after him and find ... "
HTS Teologiese Studies/Theological Studies, 2001 The aim of this article is to investigate the allusion to the possibility of touching God ψηλαϕάω in Paul's Areopagus speech (Acts 17:27). The article aims at assessing the Lukan notion of God's nearness in space and time.
Sjef van Tilborg
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source