Results 61 to 70 of about 4,285 (257)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

An Improved Nearness Grey Incidence Model and Its Application in the Analysis of Air Pollutants in Beijing-Tianjin-Hebei Region

Atmosphere
A new nearness grey incidence model that not only measures the degree of correlation but also measures the direction is proposed to analyze the distribution characteristics of air pollutants in the Beijing–Tianjin–Hebei region, from 2016 to 2024.
Siqi Wang, Jing Sun, Chao Hua
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Apropierea și întârzierea „Parousiei” la părinții ante- și post-niceeni – partea a 2-a [Nearness and Delay of "Parousia" in Pre- and Post-Nicene Fathers – Part 2]

TheoRhēma, 2016
he concepts of the nearness and delay of parusia in the thought of the ante- and post-Nicene Fathers, dealt with in part one, have here been taken up again, this time with a focus on the way the Nicene and post-Nicene Fathers related to the nearness and
Laurențiu Moț
doaj  

An Application for Descriptive Nearness: Iris Recognition

Topological Algebra and its Applications, 2017
Near Set Theory has various applications in the literature. In this paper, using the concept descriptive nearness, we show how to perform iris recognition. This process has a few algorithms given via Mathematica Script Language.
Polat Kadirhan
doaj   +1 more source

Emotional Branding as an Effort to Improve the Quality of Library Service in Order to Increase the Use of Library

Record and Library Journal, 2018
This paper is a study of implementation of emotional branding in library services.    Emotional branding is a new paradigm in marketing world. It means create emotional nuance and its objective is to create an emotional nearness between a brand and its ...
Neneng Komariah, Saleha Rodiyah, Encang Saepuddin   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Apropierea și întârzierea „Parousiei” la părinții ante- și post-niceeni – partea 1 [Nearness and Delay of "Parousia" in Pre- and Post-Nicene Fathers – Part 1]

TheoRhēma, 2016
Nearness and delay of the parousia for ante and post-Nicene fathers, part one, is an article about how the apostolic and the early Church Fathers perceive the second coming of Jesus in terms of closeness and delay.
Laurențiu Moț
doaj