Results 81 to 90 of about 7,318 (296)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Record and Library Journal, 2018 This paper is a study of implementation of emotional branding in library services. Emotional branding is a new paradigm in marketing world. It means create emotional nuance and its objective is to create an emotional nearness between a brand and its ...
Neneng Komariah +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Nearness structures and proximity extensions
, 1975 Proximity, contiguity and nearness structures are here studied from a unified point of view. In the discussion the role that grills can play in the theory is emphasized. Nearness structures were recently introduced by Herrlich and Naimpally.
W. J. Thron, M. S. Gagrat
core +1 more source
TheoRhēma, 2016 he concepts of the nearness and delay of parusia in the thought of the ante- and post-Nicene Fathers, dealt with in part one, have here been taken up again, this time with a focus on the way the Nicene and post-Nicene Fathers related to the nearness and
Laurențiu Moț
doaj
An Application for Descriptive Nearness: Iris Recognition
Topological Algebra and its Applications, 2017 Near Set Theory has various applications in the literature. In this paper, using the concept descriptive nearness, we show how to perform iris recognition. This process has a few algorithms given via Mathematica Script Language.
Polat Kadirhan
doaj +1 more source
Nearest Neighbor Search in the Metric Space of a Complex Network for Community Detection
Information, 2016 The objective of this article is to bridge the gap between two important research directions: (1) nearest neighbor search, which is a fundamental computational tool for large data analysis; and (2) complex network analysis, which deals with large real ...
Suman Saha, Satya P. Ghrera
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
TheoRhēma, 2016 Nearness and delay of the parousia for ante and post-Nicene fathers, part one, is an article about how the apostolic and the early Church Fathers perceive the second coming of Jesus in terms of closeness and delay.
Laurențiu Moț
doaj
AtmosphereA new nearness grey incidence model that not only measures the degree of correlation but also measures the direction is proposed to analyze the distribution characteristics of air pollutants in the Beijing–Tianjin–Hebei region, from 2016 to 2024.
Siqi Wang, Jing Sun, Chao Hua
doaj +1 more source