Results 1 to 10 of about 4,374 (166)

Nebivolol Protects the Thoracic and Abdominal Aorta and Their Perivascular Adipose Tissue From the Differential Detrimental Effects of Obesity. [PDF]

Fundam Clin Pharmacol
ABSTRACT The effects of obesity on the vasculature and perivascular adipose tissue (PVAT) function vary according to the vascular territory. Nebivolol is a third‐generation β‐blocker that exerts vasculoprotective effects in obesity. The thoracic and abdominal aorta show different responses under physiological conditions, and their PVATs have a ...
Dourado TMH, Pimenta GF, Silva LP, Assis VO, Silva AO, Tirapelli CR.   +5 more
europepmc   +2 more sources

Nebivolol suppresses glioblastoma progression via dual modulation of mitochondrial metabolism and AKT/mTOR/4EBP1 signaling axis. [PDF]

PLoS Genetics
Emerging evidence reveals the pivotal involvement of mitochondrial metabolic dysregulation in glioblastoma (GBM) pathogenesis, considering mitochondrial metabolism as a potential therapeutic target.
Lingni Zhou, Hongyu Che, Hongyan Jiang, Luxin Yin, Yongang Jiang, Yuhui Zhang, Haoran Liang, Rutong Yu, Xu Zhang, Xuejiao Liu   +9 more
doaj   +2 more sources

Mechanisms of nebivolol-mediated effects on bFGF-induced vascular smooth muscle cell proliferation and migration [PDF]

Current Research in Pharmacology and Drug Discovery
Background: Nebivolol is a β-adrenergic receptor antagonist that has intrinsic activity on β3-adrenergic receptors (β3-ARs). Previous studies suggest that nebivolol inhibits bFGF-induced vascular smooth muscle cell (VSMC) proliferation and migration and ...
Elaina Seemann, Trevor Beeler, Mohammed Alfarra, Mark Cosio, Charles Chan, Peyton Grant, Yingzi Chang   +6 more
doaj   +2 more sources

Plaque Morphology-Dependent Regression of Tandem Coronary Plaques Under Intensive Lipid-Lowering Therapy. [PDF]

Catheter Cardiovasc Interv
ABSTRACT We report a 54‐year‐old woman with stable angina who exhibited heterogeneous responses of tandem left anterior descending artery (LAD) plaques to intensive lipid‐lowering therapy. Coronary CT angiography performed at another hospital suggested diffuse disease, and she presented to our clinic for a second opinion.
Kim YL, Noh HW, Seo CO, Park JR, Kim K, Kim HR, Hwang JY, Kang MG, Kim H, Koh JS.   +9 more
europepmc   +2 more sources

Differential effects of β-blockers nebivolol and metoprolol on mitochondrial biogenesis and antioxidant defense in angiotensin II-induced pathology in H9c2 cardiomyoblasts [PDF]

BMC Pharmacology and Toxicology
Background Mitochondrial dysfunction and oxidative stress induced by overactivation of angiotensin II (Ang II) are major contributors to the progression of cardiovascular diseases (CVD).
Rukhsana Gul, Arwa Bazighifan, Shahid Nawaz, Assim A. Alfadda   +3 more
doaj   +2 more sources

Inhibition of eNOS Partially Blunts the Beneficial Effects of Nebivolol on Angiotensin II-Induced Signaling in H9c2 Cardiomyoblasts

Current Issues in Molecular Biology, 2022
We have recently illustrated that nebivolol can inhibit angiotensin II (Ang II)-mediated signaling in cardiomyoblasts; however, to date, the detailed mechanism for the beneficial effects of nebivolol has not been studied.
Rukhsana Gul, Nouf Alsalman, Assim A. Alfadda   +2 more
doaj   +1 more source

Nebivolol protects against myocardial infarction injury via stimulation of beta 3-adrenergic receptors and nitric oxide signaling. [PDF]

PLoS ONE, 2014
Nebivolol, third-generation β-blocker, may activate β3-adrenergic receptor (AR), which has been emerged as a novel and potential therapeutic targets for cardiovascular diseases.
Zheng Zhang, Liping Ding, Zhitao Jin, Guojie Gao, Huijun Li, Lijuan Zhang, Lina Zhang, Xin Lu, Lihua Hu, Bingwei Lu, Xiongjun Yu, Taohong Hu   +11 more
doaj   +1 more source

Anticonvulsant Effect of Nebivolol alone and in Combination with Phenytoin against Maximal Electroshock-Induced Seizures in Mice [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Phenytoin is widely used in treatment of generalised tonic clonic seizures but its adverse effects make its usage limited. Hence forth, there is a need for newer antiepileptics. Studies have shown antiepileptic property for nebivolol in
Anuranjani Dhamodharan, Nitya Selvaraj, R Meenakshi   +2 more
doaj   +1 more source

The β-blocker Nebivolol Is a GRK/β-arrestin biased agonist. [PDF]

PLoS ONE, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Catherine E Erickson, Rukhsana Gul, Christopher P Blessing, Jenny Nguyen, Tammy Liu, Lakshmi Pulakat, Murat Bastepe, Edwin K Jackson, Bradley T Andresen   +8 more
doaj   +1 more source

Nitric oxide mediated the effects of nebivolol in cardiorenal syndrome [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), the exact mechanism remains unclear. Nitrosative stress has been argued as a key mechanism recently.
Guldem Mercanoglu, Semen Onder
doaj   +1 more source