The β-blocker Nebivolol Is a GRK/β-arrestin biased agonist. [PDF]
PLoS ONE, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Catherine E Erickson +8 more
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The Beta-1-Receptor Blocker Nebivolol Elicits Dilation of Cerebral Arteries by Reducing Smooth Muscle [Ca2+]i. [PDF]
PLoS ONE, 2016 Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it elicits relaxation of the peripheral arteries in part via release of nitric oxide (NO).
Peter Cseplo +5 more
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Current Issues in Molecular Biology, 2022 We have recently illustrated that nebivolol can inhibit angiotensin II (Ang II)-mediated signaling in cardiomyoblasts; however, to date, the detailed mechanism for the beneficial effects of nebivolol has not been studied.
Rukhsana Gul +2 more
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Mechanisms of nebivolol-mediated effects on bFGF-induced vascular smooth muscle cell proliferation and migration [PDF]
Current Research in Pharmacology and Drug DiscoveryBackground: Nebivolol is a β-adrenergic receptor antagonist that has intrinsic activity on β3-adrenergic receptors (β3-ARs). Previous studies suggest that nebivolol inhibits bFGF-induced vascular smooth muscle cell (VSMC) proliferation and migration and ...
Elaina Seemann +6 more
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Differential effects of β-blockers nebivolol and metoprolol on mitochondrial biogenesis and antioxidant defense in angiotensin II-induced pathology in H9c2 cardiomyoblasts [PDF]
BMC Pharmacology and ToxicologyBackground Mitochondrial dysfunction and oxidative stress induced by overactivation of angiotensin II (Ang II) are major contributors to the progression of cardiovascular diseases (CVD).
Rukhsana Gul +3 more
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Nebivolol induced hyperkalemia: case report
Acta Clinica Croatica, 2016 In this article, we document a conclusive case of nebivolol-induced hyperkalemia for the first time in the known medical literature. Hyperkalemia is associated with serious conditions such as cardiac arrhythmias and sudden cardiac death.
Karmela Altabas +2 more
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Anticonvulsant Effect of Nebivolol alone and in Combination with Phenytoin against Maximal Electroshock-Induced Seizures in Mice [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Phenytoin is widely used in treatment of generalised tonic clonic seizures but its adverse effects make its usage limited. Hence forth, there is a need for newer antiepileptics. Studies have shown antiepileptic property for nebivolol in
Anuranjani Dhamodharan +2 more
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Nebivolol protects against myocardial infarction injury via stimulation of beta 3-adrenergic receptors and nitric oxide signaling. [PDF]
PLoS ONE, 2014 Nebivolol, third-generation β-blocker, may activate β3-adrenergic receptor (AR), which has been emerged as a novel and potential therapeutic targets for cardiovascular diseases.
Zheng Zhang +11 more
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Nitric oxide mediated the effects of nebivolol in cardiorenal syndrome [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), the exact mechanism remains unclear. Nitrosative stress has been argued as a key mechanism recently.
Guldem Mercanoglu, Semen Onder
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Beneficial Effects of Nebivolol in Comparison with Atenolol on Safety and Tolerability in Essential Hypertension [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: Hypertension, “The silent killer” is a multifactorial disorder which is asymptomatic and if left untreated leads to lethal complications.
Vivek V. Bhosale +5 more
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