Results 11 to 20 of about 14,058 (258)

Treatment with β-blocker nebivolol ameliorates oxidative stress and endothelial dysfunction in tenofovir-induced nephrotoxicity in rats

Frontiers in Medicine, 2022
BackgroundTenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens, has been associated with nephrotoxicity. Nebivolol is a third generation selective β-1 adrenergic receptor blocker and may protect renal structure ...
Mariana Moura Nascimento, Desiree Rita Denelle Bernardo, Ana Carolina de Bragança, Maria Heloisa Massola Shimizu, Antonio Carlos Seguro, Rildo Aparecido Volpini, Daniele Canale   +6 more
doaj   +2 more sources

Nebivolol, an FDA-Approved Drug, Has General Antibacterial and Antibiofilm Effects and Increases Pseudomonas aeruginosa Tolerance to Ciprofloxacin

Pharmaceuticals
Background: The repurposing of approved drugs for new activities is gaining widespread attention, including drugs that have antibacterial properties. Nevertheless, besides the benefits of repurposing drugs, the discovery of new antibiotic activity in ...
Yael Schlichter Kadosh, Noa Goorevitch, Kerem Teralı, Jacob Gopas, Ariel Kushmaro   +4 more
doaj   +2 more sources

Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review

Discover Chemistry
Nebivolol, a beta-blocker commonly prescribed for the treatment of hypertension and heart failure, functions by decelerating heart rate and promoting vasodilation, thereby enhancing blood flow and reducing blood pressure.
Kurdo A. Abdullah, Aryan Fathulla Qader, Rebaz Anwar Omer, Rebaz Obaid Kareem, Musher Ismael Salih   +4 more
doaj   +2 more sources

Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds. [PDF]

Angew Chem Int Ed Engl
Various substituted chromane‐2‐carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was applied to the concise enantioselective synthesis of five active pharmaceutical ingredients.
Ghosh B, Iglhaut M, Babushkina D, Pauls M, Bannwarth C, Bach T.   +5 more
europepmc   +3 more sources

Design, Characterization and Pharmacokinetic–Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of Nebivolol for Treatment of Open-Angle Glaucoma

Pharmaceutics, 2023
This study developed a dual-responsive in situ gel of nebivolol (NEB), a selective β-adrenergic antagonist. The gel could achieve sustained concentrations in the aqueous humor to effectively treat glaucoma.
P. Rawat, P. Ravi, Shahid Iqbal Mir, M. S. Khan, Himanshu Kathuria, P. Katnapally, U. Bhatnagar   +6 more
semanticscholar   +1 more source

Blockade of ß-Adrenergic Receptors by Nebivolol Enables Tumor Control Potential for Uveal Melanoma in 3D Tumor Spheroids and 2D Cultures

International Journal of Molecular Sciences, 2023
Uveal melanoma (UM) is the most common primary cancer of the eye in adults. A new systemic therapy is needed to reduce the high metastasis and mortality rate.
Lina S. Farhoumand, Hongtao Liu, Theodora Tsimpaki, U. Hendgen-Cotta, T. Rassaf, N. Bechrakis, Miltiadis Fiorentzis, U. Berchner‐Pfannschmidt   +7 more
semanticscholar   +1 more source

Ameliorative effect of nebivolol in doxorubicin-induced cardiotoxicity

Journal of Medicine and Life, 2023
This study aimed to investigate the potential of nebivolol in preventing doxorubicin-induced cardiotoxicity by targeting the inflammatory, oxidative, and apoptotic pathways.
H. Al-amir, Ali M. Janabi, N. Hadi
semanticscholar   +1 more source

Nebivolol Alleviates Vascular Endothelial Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress.

International Heart Journal, 2023
Vascular endothelial insulin resistance (IR) is an important risk factor in the development of vascular complications in diabetes. Prolonged endoplasmic reticulum stress (ERS) contributes to the development and progression of endothelial IR.
Xinxin Li, Qiuping Li, Lijuan Wu, Yan Wang   +3 more
semanticscholar   +1 more source

Analysis of Nebivolol hydrochloride and Valsartan in Pharmaceutical Dosage Form by High Performance Thin Layer Chromatographic Method [PDF]

, 2011
A simple, accurate and precise high performance thin layer chromatographic method has been developed for the estimation of Valsartan and Nebivolol hydrochloride simultaneously from a tablet dosage form.
Alok Mukerjee, Anil Singh, Mrinalini Damle, Shanti Mishra, Shradhanjali Singh, Shradhanjali Singh   +5 more
core   +2 more sources

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source