Results 111 to 120 of about 5,338 (235)

Interplay Between Cyclase-Associated Protein, Cofilin, Profilin and Twinfilin in Actin Dynamics [PDF]

, 2013
The ability of actin to form dynamic networks is crucial for processes including cell migration, endocytosis and cell division. Furthermore, in sarcomeres of muscle cells, actin and myosin form interdigitating networks responsible for muscle contraction.
Makkonen, Maarit
core  

Linking genetics with biology in disease research: an interview with Nick Hastie [PDF]

, 2012
Professor Nick Hastie is Director of the MRC Human Genetics Unit in Edinburgh, a centre originally famous for early studies of chromosome biology. He is also Director of the newly formed Institute of Genetics and Molecular Medicine, which includes the ...
Allan, Sarah, Hastie, Nick
core   +3 more sources

Nebulin as a giant actin‐binding template protein in skeletal muscle sarcomere Interaction of actin and cloned human nebulin fragments

FEBS Letters, 1991
Nebulin is a family of giant sarcomere matrix proteins of 6OO–900 kDa in most vertebrate skeletal muscles. Recent sequence analysis suggests that human nebulin is mainly composed of a large number (> 200) of conserved repeats of ∼ 35 residues. Two cloned nebulin fragments, consisting of 6 and 8 of the repeats, have been expressed in E.
Jin, Jian-Ping, Wang, Kuan
openaire   +2 more sources

Generation of a biallelic NRAP-knockout mutant from a human iPSC line

Stem Cell Research
Cardiomyopathies, a leading cause of mortality, are associated with dysfunctional intercalated discs, which connect neighbouring cardiomyocytes and ensure proper contractility.
Janice Raabe, Vanessa Lewandowski, Sigrid Fuchs, Alexandra Hammerschmidt, Angelika Piasecki, Ellen Orthey, Elisabeth Krämer, Elisabeth Ehler, Friederike Cuello   +8 more
doaj   +1 more source

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue [PDF]

, 2016
Severe malaria due to Plasmodium falciparum infection remains a serious threat to health worldwide and new therapeutic targets are highly desirable. Small molecule inhibitors of prenyl transferases, enzymes that catalyze the post-translational isoprenyl ...
Distefano, Mark D, Odom John, Audrey R, Palsuledesai, Charuta C, Schaber, Chad, Suazo, Kiall F   +4 more
core   +2 more sources

A Reliable Targeted Next-Generation Sequencing Strategy for Diagnosis of Myopathies and Muscular Dystrophies, Especially for the Giant Titin and Nebulin Genes [PDF]

, 2018
Reda Zenagui, Delphine Lacourt, Henri Pégeot, Kévin Yauy, Raúl Juntas‐Morales, Corine Theze, François Rivier, Claude Cancés, Guilhem Solé, Dimitri Renard, Ulrike Walther‐Louvier, Xavier Ferrer-Monasterio, Caroline Espil, Marie‐Christine Arné‐Bes, Pascal Cintas, Emmanuelle Uro‐Coste, Marie-Laure Martin Négrier, Valérie Rigau, Éric Bieth, Cyril Goizet, Mireille Claustres, M. Kœnig, Mireille Cossée   +22 more
openalex   +1 more source

Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry [PDF]

, 2008
We have conducted proteome-wide analysis of fresh surgery specimens derived from breast cancer patients, using an approach that integrates size-based intact protein fractionation, nanoscale liquid separation of peptides, electrospray ion trap mass ...
Aebersold R., Boyle E. I., Chong P. K., Cottingham K., Cove D. H., Ezeh U. I., Foran E., Gygi S. P., Ioachim E., Jacobs J. M., Keller A., Laemmli U. K., Lapillonne A., Lin C. S., Liu H., Maclean B., Mathelin C., Metodiev M. V., old W. M., Patterson S. D., Pedrioli P. G., Rauch A., Schmidt A., Sealfon R. S., Seo J., Sheen-Cheen S. M., Silva J., Taylor M. R., Toi M., Wolters D. A., Zhang J.   +30 more
core   +1 more source

Nebulin as an actin zipper. A two-module nebulin fragment promotes actin nucleation and stabilizes actin filaments.

Journal of Biological Chemistry, 1993
Nebulin is a family of giant muscle proteins (700-900 kDa) that interact with actin to form composite thin filaments in the skeletal muscle sarcomere. This modular protein is composed predominantly of repeating sequence modules of 31-38 residues. To understand the minimum size and number of sequence modules that are required for actin interaction, we ...
M J, Chen, C L, Shih, K, Wang
openaire   +2 more sources

A Childhood-Onset Nemaline Myopathy Caused by Novel Compound Heterozygote Variants in the Nebulin Gene [PDF]

, 2023
Jing Xu, Jie Wu, Xiaowen Li, Wei Jiang, Chunyang Wang   +4 more
openalex   +1 more source

A peptidomic approach to discover the potential biomolecular signatures discriminating in-bag dry- and wet-aged lamb

Food Chemistry Advances
The study assessed the peptidomic profile of in-bag dry-aged (2 °C, RH 75 %, 0.5 m.s−1, n = 30) and wet-aged (-1.5 °C, n = 30) lamb with high and low levels of lipid oxidation.
Renyu Zhang, Evelyne Maes, Charles Hefer, Alasdair Noble, Ancy Thomas, Michelle J.Y. Yoo, Mustafa M. Farouk, Carolina E. Realini, Santanu Deb-Choudhury   +8 more
doaj   +1 more source