Results 1 to 10 of about 29,248 (164)

In vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle [PDF]

Frontiers in Physiology, 2016
Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at
Eng Kuan Moo, Rafael Fortuna, Scott C Sibole   +2 more
exaly   +6 more sources

Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia

Cell Reports, 2019
Summary: Precise assembly of the sarcomere, a force-generating unit in striated muscles, is critical for muscle contraction. Defective sarcomere organization is linked to myopathies and cachexia. The molecular mechanisms concerning sarcomere assembly are
Arnab Nayak, Ekaterini Kefalakes, Tim Holler   +2 more
exaly   +3 more sources

Biological properties of α-actinin-2 and its role and mechanisms in disease development [PDF]

Frontiers in Physiology
α-Actinin-2 (encoded by the ACTN2 gene) is a critical cytoskeletal protein predominantly expressed in skeletal and cardiac muscle, where it anchors actin filaments to the sarcomeric Z-disk. While its structural role is well-established, emerging evidence
Juan Meng, Shu-qiong Xu, Qi Deng, Ling-ling Jiang, Dan-Ping Huang, Qing-song Wang, Yong-Kang Wu, Yong-Kang Wu   +7 more
doaj   +2 more sources

Fluid flow in the sarcomere [PDF]

Archives of Biochemistry and Biophysics, 2021
A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that
Sage A. Malingen, Kaitlyn Hood, Eric Lauga, Anette Hosoi, Thomas L. Daniel   +4 more
openaire   +3 more sources

Variability of in vivo Sarcomere Length Measures in the Upper Limb Obtained With Second Harmonic Generation Microendoscopy

Frontiers in Physiology, 2022
The lengths of a muscle’s sarcomeres are a primary determinant of its ability to contract and produce force. In addition, sarcomere length is a critical parameter that is required to make meaningful comparisons of both the force-generating and excursion ...
Amy N. Adkins, Amy N. Adkins, Amy N. Adkins, Ryan M. Fong, Ryan M. Fong, Julius P. A. Dewald, Julius P. A. Dewald, Julius P. A. Dewald, Wendy M. Murray, Wendy M. Murray, Wendy M. Murray, Wendy M. Murray, Wendy M. Murray   +12 more
doaj   +1 more source

Sarcomeric versus Non-Sarcomeric HCM

Cardiogenetics, 2023
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions. HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins ...
Borrelli, Felice, Losi, Maria Angela, Canciello, Grazia, Todde, Gaetano, Perillo, Errico Federico, Ordine, Leopoldo, Frisso, Giulia, Esposito, Giovanni, Lombardi, Raffaella   +8 more
openaire   +3 more sources

Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres [PDF]

Biophysical Journal, 2020
The smallest contractile unit in striated muscles is the sarcomere. Although some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length nonuniformities has been well recognized for years, but it is yet not well understood. In the past years, there has been a great advance in
Felipe de Souza Leite, Dilson E. Rassier
openaire   +2 more sources

Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity

Open Heart, 2021
Background Despite advances in our understanding of the genetic causes of hypertrophic cardiomyopathy (HCM), a large portion of this patient population do not carry sarcomere gene mutations when screened.
Alejandro E de Feria, Andrew E Kott, Jason R Becker   +2 more
doaj   +1 more source

Muscle in Variable Gravity: “I Do Not Know Where I Am, But I Know What to Do”

Frontiers in Physiology, 2021
Purpose: Fascicle and sarcomere lengths are important predictors of muscle mechanical performance. However, their regulation during stretch-shortening cycle (SSC) activities in usual and challenging conditions is poorly understood.
Elena Monti, Janice Waldvogel, Ramona Ritzmann, Ramona Ritzmann, Kathrin Freyler, Kirsten Albracht, Kirsten Albracht, Michael Helm, Niccolò De Cesare, Piero Pavan, Carlo Reggiani, Albert Gollhofer, Marco Vincenzo Narici   +12 more
doaj   +1 more source

Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) volume overload (VO), commonly found in patients with chronic aortic regurgitation (AR), leads to a series of left ventricular (LV) pathological responses and eventually irreversible LV dysfunction.
Yuqing Hu, Debao Li, Chunxia Zhou, Yingying Xiao, Sijuan Sun, Chuan Jiang, Chuan Jiang, Chuan Jiang, Lijun Chen, Jinfen Liu, Hao Zhang, Hao Zhang, Fen Li, Haifa Hong, Lincai Ye, Lincai Ye, Lincai Ye   +16 more
doaj   +1 more source