Results 1 to 10 of about 51,464 (286)

In vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle

Frontiers in Physiology, 2016
Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at
Eng Kuan Moo, Rafael Fortuna, Scott C Sibole   +2 more
exaly   +3 more sources

Variability of in vivo Sarcomere Length Measures in the Upper Limb Obtained With Second Harmonic Generation Microendoscopy

Frontiers in Physiology, 2022
The lengths of a muscle’s sarcomeres are a primary determinant of its ability to contract and produce force. In addition, sarcomere length is a critical parameter that is required to make meaningful comparisons of both the force-generating and excursion ...
Amy N. Adkins, Amy N. Adkins, Amy N. Adkins, Ryan M. Fong, Ryan M. Fong, Julius P. A. Dewald, Julius P. A. Dewald, Julius P. A. Dewald, Wendy M. Murray, Wendy M. Murray, Wendy M. Murray, Wendy M. Murray, Wendy M. Murray   +12 more
doaj   +1 more source

Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity

Open Heart, 2021
Background Despite advances in our understanding of the genetic causes of hypertrophic cardiomyopathy (HCM), a large portion of this patient population do not carry sarcomere gene mutations when screened.
Alejandro E de Feria, Andrew E Kott, Jason R Becker   +2 more
doaj   +1 more source

Muscle in Variable Gravity: “I Do Not Know Where I Am, But I Know What to Do”

Frontiers in Physiology, 2021
Purpose: Fascicle and sarcomere lengths are important predictors of muscle mechanical performance. However, their regulation during stretch-shortening cycle (SSC) activities in usual and challenging conditions is poorly understood.
Elena Monti, Janice Waldvogel, Ramona Ritzmann, Ramona Ritzmann, Kathrin Freyler, Kirsten Albracht, Kirsten Albracht, Michael Helm, Niccolò De Cesare, Piero Pavan, Carlo Reggiani, Albert Gollhofer, Marco Vincenzo Narici   +12 more
doaj   +1 more source

Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload

Frontiers in Cardiovascular Medicine, 2022
BackgroundLeft ventricular (LV) volume overload (VO), commonly found in patients with chronic aortic regurgitation (AR), leads to a series of left ventricular (LV) pathological responses and eventually irreversible LV dysfunction.
Yuqing Hu, Debao Li, Chunxia Zhou, Yingying Xiao, Sijuan Sun, Chuan Jiang, Chuan Jiang, Chuan Jiang, Lijun Chen, Jinfen Liu, Hao Zhang, Hao Zhang, Fen Li, Haifa Hong, Lincai Ye, Lincai Ye, Lincai Ye   +16 more
doaj   +1 more source

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

eLife, 2022
Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large mechanical forces.
Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana Gupta, Pierre-François Lenne, Bianca H Habermann, Olivier Theodoly, Olivier Pourquié, Frank Schnorrer   +16 more
doaj   +1 more source

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy. [PDF]

, 2014
BACKGROUND: Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH).
Bassett, P, Bluemke, DA, Canter, CE, Captur, G, Day, SM, Elliott, PM, Esteban, MT, Ferreira, VM, Finocchiaro, G, Ho, CY, Li, C, Lopes, LR, McKenna, WJ, Mohun, TJ, Moon, JC, Muthurangu, V, Patel, V, Seidman, CE, Sherrid, MV   +18 more
core   +1 more source

Biomechanical Properties of the Sarcolemma and Costameres of Skeletal Muscle Lacking Desmin

Frontiers in Physiology, 2021
Intermediate filaments (IFs), composed primarily by desmin and keratins, link the myofibrils to each other, to intracellular organelles, and to the sarcolemma.
Karla P. Garcia-Pelagio, Robert J. Bloch
doaj   +1 more source

Revisiting Frank–Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion [PDF]

, 2016
Force and power in cardiac muscle have a known dependence on phosphorylation of the myosin-associated regulatory light chain (RLC). We explore the effect of RLC phosphorylation on the ability of cardiac preparations to redevelop force (ktr ) in maximally
Abraham, Adhikari, Aoki, Araujo, Barany, Blue, Bremel, Brenner, Brenner, Colson, Curtin, Davis, Ding, Ferenczi, Fitzsimons, Greenberg, Greenberg, Gu, Guccione, Hanft, Hanft, He, Hidalgo, Hooijman, Huang, Huxley, Huxley, Ishijima, Karabina, Katz, Kentish, Korte, Levine, Mansfield, Metzger, Milani-Nejad, Morano, Morano, Moss, Muthu, Nag, Nishio, Nyitrai, Okamoto, Olsson, Pate, Patel, Podolsky, Prakash, Prakash, Pulcastro, Regnier, Regnier, Regnier, Rhodes, Sanbe, Scruggs, Sheikh, Sheikh, Sonnenblick, Stelzer, Stelzer, Stracher, Sweeney, Takagi, Toepfer, Tombe, Tombe, Ueno, Wang, Warren, Wolff, Yuan   +72 more
core   +1 more source

Volume overload impedes the maturation of sarcomeres and T-tubules in the right atria: a potential cause of atrial arrhythmia following delayed atrial septal defect closure

Frontiers in Physiology, 2023
Introduction: Adult patients with atrial septal defects (ASD), the most common form of adult congenital heart disease, often die of arrhythmias, and the immaturity of cardiomyocytes contributes significantly to arrhythmias.
Zhuoya Dong, Dian Chen, Sixie Zheng, Zheng Wang, Debao Li, Yingying Xiao, Sijuan Sun, Lincai Ye, Lincai Ye, Lincai Ye, Lisheng Qiu, Yuqing Hu, Haifa Hong, Haifa Hong   +13 more
doaj   +1 more source