Results 1 to 10 of about 29,455 (242)
In vivo Sarcomere Lengths and Sarcomere Elongations Are Not Uniform across an Intact Muscle [PDF]
Frontiers in Physiology, 2016 Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at
Eng Kuan Moo +2 more
exaly +6 more sources
Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia
Cell Reports, 2019 Summary: Precise assembly of the sarcomere, a force-generating unit in striated muscles, is critical for muscle contraction. Defective sarcomere organization is linked to myopathies and cachexia. The molecular mechanisms concerning sarcomere assembly are
Ekaterini Kefalakes +2 more
exaly +3 more sources
Biological properties of α-actinin-2 and its role and mechanisms in disease development [PDF]
Frontiers in Physiologyα-Actinin-2 (encoded by the ACTN2 gene) is a critical cytoskeletal protein predominantly expressed in skeletal and cardiac muscle, where it anchors actin filaments to the sarcomeric Z-disk. While its structural role is well-established, emerging evidence
Juan Meng +7 more
doaj +2 more sources
Frontiers in Physiology, 2022 The lengths of a muscle’s sarcomeres are a primary determinant of its ability to contract and produce force. In addition, sarcomere length is a critical parameter that is required to make meaningful comparisons of both the force-generating and excursion ...
Amy N. Adkins +12 more
doaj +1 more source
Fluid flow in the sarcomere [PDF]
Archives of Biochemistry and Biophysics, 2021 A highly organized and densely packed lattice of molecular machinery within the sarcomeres of muscle cells powers contraction. Although many of the proteins that drive contraction have been studied extensively, the mechanical impact of fluid shearing within the lattice of molecular machinery has received minimal attention. It was recently proposed that
Sage A. Malingen +4 more
openaire +4 more sources
Sarcomeric versus Non-Sarcomeric HCM
Cardiogenetics, 2023 Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions. HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins ...
Borrelli, Felice +8 more
openaire +3 more sources
Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres [PDF]
Biophysical Journal, 2020 The smallest contractile unit in striated muscles is the sarcomere. Although some of the classic features of contraction assume a uniform behavior of sarcomeres within myofibrils, the occurrence of sarcomere length nonuniformities has been well recognized for years, but it is yet not well understood. In the past years, there has been a great advance in
Felipe de Souza Leite, Dilson E. Rassier
openaire +2 more sources
Sarcomere mutation negative hypertrophic cardiomyopathy is associated with ageing and obesity
Open Heart, 2021 Background Despite advances in our understanding of the genetic causes of hypertrophic cardiomyopathy (HCM), a large portion of this patient population do not carry sarcomere gene mutations when screened.
Alejandro E de Feria +2 more
doaj +1 more source
Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload
Frontiers in Cardiovascular Medicine, 2022 BackgroundLeft ventricular (LV) volume overload (VO), commonly found in patients with chronic aortic regurgitation (AR), leads to a series of left ventricular (LV) pathological responses and eventually irreversible LV dysfunction.
Yuqing Hu +16 more
doaj +1 more source
Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers
eLife, 2022 Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large mechanical forces.
Qiyan Mao +16 more
doaj +1 more source