Results 11 to 20 of about 29,455 (242)
Biomechanical Properties of the Sarcolemma and Costameres of Skeletal Muscle Lacking Desmin
Frontiers in Physiology, 2021 Intermediate filaments (IFs), composed primarily by desmin and keratins, link the myofibrils to each other, to intracellular organelles, and to the sarcolemma.
Karla P. Garcia-Pelagio, Robert J. Bloch
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Distorting the sarcomere [PDF]
Journal of General Physiology, 2010 One of the goals of cardiovascular science is to create a mathematical model of the heart that can predict ventricular function in healthy and diseased states, and that can be used to help improve treatment options for patients with heart disease. To be clinically useful, the model will have to include structural information about the shapes of the ...
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Active Viscoelasticity of Sarcomeres [PDF]
Frontiers in Robotics and AI, 2018 The perturbation response of muscle is important for the versatile, stable and agile control capabilities of animals. Muscle resists being stretched by developing forces in the passive tissues and in the active crossbridges. This review focuses on the active perturbation response of the sarcomere. The active response exhibits typical stress relaxation,
Khoi D. Nguyen 0002 +2 more
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Frontiers in Physiology, 2023 Introduction: Adult patients with atrial septal defects (ASD), the most common form of adult congenital heart disease, often die of arrhythmias, and the immaturity of cardiomyocytes contributes significantly to arrhythmias.
Zhuoya Dong +13 more
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Cell Reports, 2021 Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes.
Feria A. Ladha +9 more
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Scientific Reports, 2020 When a muscle is stretched during a contraction, the resulting steady-state force is higher than the isometric force produced at a comparable sarcomere length.
Ricarda M. Haeger, Dilson E. Rassier
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Spontaneous sarcomere dynamics [PDF]
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2010 Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state.
Gunther, Stefan, Kruse, Karsten
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eLife, 2023 Palladin (PALLD) belongs to the PALLD/myopalladin (MYPN)/myotilin family of actin-associated immunoglobulin-containing proteins in the sarcomeric Z-line.
Giuseppina Mastrototaro +14 more
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Myomesin is part of an integrity pathway that responds to sarcomere damage and disease.
PLoS ONE, 2019 The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.
Kendal Prill +4 more
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Muscle in Variable Gravity: “I Do Not Know Where I Am, But I Know What to Do”
Frontiers in Physiology, 2021 Purpose: Fascicle and sarcomere lengths are important predictors of muscle mechanical performance. However, their regulation during stretch-shortening cycle (SSC) activities in usual and challenging conditions is poorly understood.
Elena Monti +12 more
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