Results 11 to 20 of about 50 (46)
The sarcomeric cytoskeleton: from molecules to motion
Journal of Experimental Biology, 2016 ABSTRACT Highly ordered organisation of striated muscle is the prerequisite for the fast and unidirectional development of force and motion during heart and skeletal muscle contraction. A group of proteins, summarised as the sarcomeric cytoskeleton, is essential for the ordered assembly of actin and myosin filaments into sarcomeres, by ...
Gautel, Mathias +1 more
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On the mechanics of single sarcomeres.
Molecular & cellular biomechanics : MCB, 2010 This article has no abstract.
W. Herzog +2 more
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Sarcomeric TPM3α in developing chicken [PDF]
Cytoskeleton, 2017 AbstractCloning and sequencing of various tropomyosin isoforms expressed in chickens have been described since the early 1980s. However, to the best of our knowledge, this is the first report on the molecular characterization and the expression of the sarcomeric isoform of the TPM3 gene in cardiac and skeletal muscles from developing as well as adult ...
Syamalima, Dube +8 more
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Breaking sarcomeres by in vitro exercise [PDF]
Scientific Reports, 2016 AbstractEccentric exercise leads to focal disruptions in the myofibrils, referred to as “lesions”. These structures are thought to contribute to the post-exercise muscle weakness and to represent areas of mechanical damage and/or remodelling. Lesions have been investigated in human biopsies and animal samples after exercise. However, this approach does
Zacharias Orfanos +7 more
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Redox Signaling and Cardiac Sarcomeres [PDF]
Journal of Biological Chemistry, 2011 Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis.
Marius P, Sumandea, Susan F, Steinberg
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Divergent Regulation of the Sarcomere and the Cytoskeleton [PDF]
Journal of Biological Chemistry, 2008 The existence of a feedback mechanism regulating the precise amounts of muscle structural proteins, such as actin and the actin-associated protein tropomyosin (Tm), in the sarcomeres of striated muscles is well established. However, the regulation of nonmuscle or cytoskeletal actin and Tms in nonmuscle cell structures has not been elucidated.
Galina, Schevzov +13 more
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Sarcomeric dysfunction in heart failure [PDF]
Cardiovascular Research, 2007 Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and
Hamdani, N. +8 more
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Sarcomeric proteins and inherited cardiomyopathies [PDF]
Cardiovascular Research, 2007 Over the last two decades, a large number of mutations have been identified in sarcomeric proteins as a cause of hypertrophic, dilated or restrictive cardiomyopathy. Functional analyses of mutant proteins in vitro have revealed several important functional changes in sarcomeric proteins that might be primarily involved in the pathogenesis of each ...
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Sarcomere Gene Mutation correction [PDF]
European Heart Journal, 2018 Sanjiv, Kaul +2 more
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