Results 41 to 50 of about 29,455 (242)
PLoS ONEThe sarcomere is the fundamental contractile unit in skeletal muscle, and the regularity of its structure is critical for function. Emerging data demonstrates that nanoscale changes to the regularity of sarcomere structure can affect the overall function
Collin M Douglas +3 more
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Hugh E. Huxley: cambiando el paradigma de la contracción muscular, desde dentro. [Hugh E. Huxley: changing from inside the paradigm of muscle contraction]. [PDF]
Revista Internacional de Ciencias del Deporte, 2014 Desde un punto de vista físico se puede entender la fibra muscular como un motor, es decir, un sistema capaz de transformar la energía química en energía mecánica, que se utiliza para realizar un trabajo.
Adolfo Araci
doaj
Bioengineering, 2021 Engineered in vitro models of skeletal muscle are essential for efficiently screening drug safety and efficacy. However, conventional culture substrates poorly replicate physical features of native muscle and do not support long-term culture, which ...
Divya Gupta +2 more
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Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells [PDF]
American Journal of Physiology-Cell Physiology, 2017 Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal ...
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Advanced Healthcare Materials, EarlyView.Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang +7 more
wiley +1 more source
Frontiers in PhysiologyThe transverse–axial tubular system (TATS) is the extension of sarcolemma growing to the cell interior, providing sufficient calcium signaling to induce calcium release from sarcoplasmic reticulum cisternae and stimulate the contraction of neighboring ...
Zuzana Sevcikova Tomaskova +1 more
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The sarcomeric cytoskeleton: from molecules to motion
Journal of Experimental Biology, 2016 ABSTRACT Highly ordered organisation of striated muscle is the prerequisite for the fast and unidirectional development of force and motion during heart and skeletal muscle contraction. A group of proteins, summarised as the sarcomeric cytoskeleton, is essential for the ordered assembly of actin and myosin filaments into sarcomeres, by ...
Gautel, Mathias +1 more
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Signalling in sarcomeres in development and disease [PDF]
Netherlands Heart Journal, 2013 Sarcomeres are the smallest contractile units of heart and skeletal muscles and are essential for generation and propagation of mechanical force in these striated muscles. During the last decades it has become increasingly clear that components of sarcomeres also play a fundamental role in signal transduction in physiological and pathophysiological ...
Eldik, W. van, Passier, R.
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Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
On the mechanics of single sarcomeres.
Molecular & cellular biomechanics : MCB, 2010 This article has no abstract.
W. Herzog +2 more
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