Results 51 to 60 of about 51,464 (286)
Effects of Low Cell pH and Elevated Inorganic Phosphate on the pCa-Force Relationship in Single Muscle Fibers at Near-Physiological Temperatures [PDF]
, 2014 Intense muscle contraction induces high rates of ATP hydrolysis with resulting increases in Pi, H+, and ADP, factors thought to induce fatigue by interfering with steps in the cross-bridge cycle.
Fitts, Robert H., Nelson, Cassandra R.
core +2 more sources
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
Instabilities and Oscillations in Isotropic Active Gels [PDF]
, 2010 We present a generic formulation of the continuum elasticity of an isotropic crosslinked active gel. The gel is described by a two-component model consisting of an elastic network coupled frictionally to a permeating fluid.
Ahmadi +47 more
core +4 more sources
Research priorities in sarcomeric cardiomyopathies [PDF]
Cardiovascular Research, 2015 The clinical variability in patients with sarcomeric cardiomyopathies is striking: a mutation causes cardiomyopathy in one individual, while the identical mutation is harmless in a family member. Moreover, the clinical phenotype varies ranging from asymmetric hypertrophy to severe dilatation of the heart. Identification of a single phenotype-associated
Van Der Velden J. +5 more
openaire +4 more sources
Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling
Advanced Healthcare Materials, EarlyView.Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee +7 more
wiley +1 more source
Chronic high‐dose testosterone treatment: impact on rat cardiac contractile biology
Physiological Reports, 2019 Androgen therapy provides cardiovascular benefits for hypogonadism. However, myocardial hypertrophy, fibrosis, and infarction have been reported in testosterone or androgenic anabolic steroid abuse.
Munthana Wadthaisong +4 more
doaj +1 more source
Bioengineering, 2021 Engineered in vitro models of skeletal muscle are essential for efficiently screening drug safety and efficacy. However, conventional culture substrates poorly replicate physical features of native muscle and do not support long-term culture, which ...
Divya Gupta +2 more
doaj +1 more source
Is High-frequency stiffness a measure for the number of attached cross-bridges? [PDF]
, 1996 Muscle stiffness is an important property for movement control. Stiffness is a measure for the resistance against mechanical disturbances in muscular-skeletal systems.
Grootenboer, H.J. +3 more
core +4 more sources
Redox Signaling and Cardiac Sarcomeres [PDF]
Journal of Biological Chemistry, 2011 Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis.
Marius P, Sumandea, Susan F, Steinberg
openaire +2 more sources