Results 71 to 80 of about 35,307 (294)

Divergent Regulation of the Sarcomere and the Cytoskeleton [PDF]

Journal of Biological Chemistry, 2008
The existence of a feedback mechanism regulating the precise amounts of muscle structural proteins, such as actin and the actin-associated protein tropomyosin (Tm), in the sarcomeres of striated muscles is well established. However, the regulation of nonmuscle or cytoskeletal actin and Tms in nonmuscle cell structures has not been elucidated.
Galina, Schevzov, Thomas, Fath, Bernadette, Vrhovski, Nicole, Vlahovich, Sudarsan, Rajan, Jeff, Hook, Josephine E, Joya, Frances, Lemckert, Franz, Puttur, Jim J-C, Lin, Edna C, Hardeman, David F, Wieczorek, Geraldine M, O'Neill, Peter W, Gunning   +13 more
openaire   +2 more sources

Tangent stiffness vs. sarcomere length.

, 2019
Tangent stiffness vs. sarcomere length for fibres (sum of fast and slow) and ECM, as obtained by the fitting procedure of Eq (9) to experimental data of bundles. The tangent stiffness is here defined as the slope of the stress vs.
Arturo N. Natali (7821905), Piero G. Pavan (7821908), Giulia Randazzo (7821902), Lorenzo Marcucci (151628), Carlo Reggiani (229464), Michela Bondì (7821899)   +5 more
core   +1 more source

Soleus collagen architecture and sarcomere length.

, 2022
Mdx soleus has greater collagen alignment and sarcomere length relates to elastic stiffness. (A) Second Harmonic Generation (SHG) representative images of soleus muscle sections from young, adult, wildtype, and mdx mice.
Sarah E. Brashear (14020307), Elias H. Jbeily (14020316), Lin-Ya Hu (14020313), Blaine A. Christiansen (13174551), Ross P. Wohlgemuth (14020310), Lucas R. Smith (8059802)   +5 more
core   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Effects of eccentric contraction on force enhancement in rat fast‐twitch muscle

Physiological Reports, 2023
The aim of this study was to elucidate the effects of eccentric contraction (ECC) on force enhancement in rat fast‐twitch skeletal muscle. Gastrocnemius (GAS) muscles were subjected to 200 ECCs in situ by electrical stimulation.
Jiayu Shi, Masanobu Wada
doaj   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Classifying Cardiac Actin Mutations Associated With Hypertrophic Cardiomyopathy

Frontiers in Physiology, 2018
Mutations in the cardiac actin gene (ACTC1) are associated with the development of hypertrophic cardiomyopathy (HCM). To date, 12 different ACTC1 mutations have been discovered in patients with HCM. Given the high degree of sequence conservation of actin
Evan A. Despond, John F. Dawson
doaj   +1 more source

Sarcomere Dysfunction in Nemaline Myopathy

Journal of Neuromuscular Diseases, 2017
Nemaline myopathy (NM) is among the most common non-dystrophic congenital myopathies (incidence 1:50.000). Hallmark features of NM are skeletal muscle weakness and the presence of nemaline bodies in the muscle fiber. The clinical phenotype of NM patients is quite diverse, ranging from neonatal death to normal lifespan with almost normal motor function.
de Winter, Josine M, Ottenheijm, Coen A C   +1 more
openaire   +5 more sources

Sarcomeric dysfunction in heart failure [PDF]

Cardiovascular Research, 2007
Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and
Hamdani, N., Kooij, V., van Dijk, S.J., Merkus, D., Paulus, W.J., Remedios, C.D., Duncker, D.J., Stienen, G.J.M., van der Velden, J.   +8 more
openaire   +4 more sources

Fibre stress vs. sarcomere length.

, 2019
a) Stress vs. sarcomere length experimental data for passive elongation of fast and slow fibres. b) Stress vs. sarcomere length experimental data of pooled fast and slow fibres compared to numerical results obtained by the fitting of Eq (1) proposed in ...
Arturo N. Natali (7821905), Piero G. Pavan (7821908), Giulia Randazzo (7821902), Lorenzo Marcucci (151628), Carlo Reggiani (229464), Michela Bondì (7821899)   +5 more
core   +1 more source