Results 81 to 90 of about 29,455 (242)

Mechanical signaling in the pathophysiology of critical illness myopathy

Frontiers in Physiology, 2016
The complete loss of mechanical stimuli of skeletal muscles, i.e., the loss of external strain, related to weight bearing, and internal strain, related to the contraction of muscle cells, is uniquely observed in pharmacologically paralyzed or deeply ...
Rebeca Corpeño Kalamgi, Lars eLarsson, Lars eLarsson   +2 more
doaj   +1 more source

Three‐dimensional digital analysis of musteloid masticatory muscle architecture

The Anatomical Record, EarlyView.
Musteloids span an enormous breadth of dietary modes within a single superfamily. In this study, we utilize digital dissection techniques to reconstruct the internal 3D anatomy of muscles within the musteloid feeding apparatus, and explore how dietary specializations might alter the size, orientation, and curvature of fascicles therein.
Cassidy E. Davis, Edwin Dickinson, Madison Manzo, Ashley R. Deutsch, Jillian S. Davis, Michael C. Granatosky, Adam Hartstone‐Rose   +6 more
wiley   +1 more source

Fascicle measurement methods do result in lengths that are significantly different

The Anatomical Record, EarlyView.
A recent comparison of the most prevalent methods for measuring fascicles, in situ measurement versus chemical digestion, concluded that the measurements are indistinguishable based on data from different conspecific individuals. However, our study of contralateral muscles of the same individuals shows that the methods clearly result in statistically ...
Katherine M. Clark, Reece A. Brown, Maggie Funderburk, Elise S. Bush, Anthony Herrel, Adam Hartstone‐Rose   +5 more
wiley   +1 more source

Student‐identified barriers to histology learning and the perceived value of coloring as a multimodal educational strategy

Anatomical Sciences Education, EarlyView.
Abstract Histology is a visually complex and cognitively demanding subject often perceived as abstract, memorization‐heavy, and disconnected from clinical practice. Despite its foundational importance, histology is frequently under‐emphasized relative to gross anatomy and lacks interactive, multimodal resources tailored to its unique challenges.
Anika Knowles, Karen Pinder, Tamara A. Franz‐Odendaal   +2 more
wiley   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice

Frontiers in Physiology, 2014
The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L Peters, Velia M Fowler   +4 more
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Myosin light chain proteins cooperatively promote sarcomere growth in fast-twitch muscle

Nature Communications
Muscle becomes stronger by expanding sarcomeres from the cell’s edge to its center. Here we investigate how Mylpf (Myosin Light Chain Phosphorylatable Fast) abundance impacts sarcomere growth.
Tayo E. Adekeye, Troy E. Hupper, Teresa E. Easterbrooks, Emily M. Teets, Emily A. Tomak, Sadie L. Waterman, Kailee A. Sprague, Angelina White, Maddison L. Coffin, Daniel K. Tanaka, Sabrina M. Varga, Mason T. Soares, Sarah J. Shepherd, Jared D. Austin, Dmitrii Krivorotko, Emma S. Perry, Sharon L. Amacher, Joshua B. Kelley, Jared C. Talbot   +18 more
doaj   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source