Results 91 to 100 of about 35,307 (294)
, 2013 Single-step stretching (dashed lines) induces a drastic change in stretch resulting in a pronounced overstress and sarcomere lengthening. Multiple-step stretching (solid lines) induces a gradual change in stretch inducing a moderate overstress and ...
Oscar J. Abilez (304734) +3 more
core +1 more source
Minimal data sets for sarcomere lengths.
, 2022 This file contains values for sarcomere length of atrium and ventricle in masu and cherry salmon, respectively. (XLSX)
Misaki Kimoto (14059573) +4 more
core +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
Sarcomere lengths in chronically stretched skeletal muscle.
, 2013 Computationally predicted sarcomere lengths agree nicely with experimentally measured sarcomere lengths with errors on the order of the experimental standard deviation [8].
Oscar J. Abilez (304734) +3 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Sarcomeric proteins and inherited cardiomyopathies [PDF]
Cardiovascular Research, 2007 Over the last two decades, a large number of mutations have been identified in sarcomeric proteins as a cause of hypertrophic, dilated or restrictive cardiomyopathy. Functional analyses of mutant proteins in vitro have revealed several important functional changes in sarcomeric proteins that might be primarily involved in the pathogenesis of each ...
openaire +2 more sources
Decreased auxotonic sarcomere shortening in hypertrophied rabbit myocardium
, 1985 Auxotonic sarcomere length change occurs during isometric twitches of isolated cardiac muscle preparations. To assess the amount of internal work in hypertrophied myocardium, we measured auxotonic sarcomere length change during isometric tension ...
B. B. Hamrell, P. B. Hultgren
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg +9 more
wiley +1 more source
Sarcomere Mechanics in Capillary Endothelial Cells
, 2009 Tension generation in endothelial cells of the aorta, spleen, and eye occurs in actin stress fibers, and is necessary for normal cell function. Sarcomeres are the tension-generating units of actin stress fibers in endothelial cells.
Lele, Tanmay P. +3 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source