Results 1 to 10 of about 13,149 (237)

HDAC6 modulates myofibril stiffness and diastolic function of the heart [PDF]

The Journal of Clinical Investigation, 2022
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin ...
Ying-Hsi Lin, Jennifer L. Major, Tim Liebner, Zaynab Hourani, Joshua G. Travers, Sara A. Wennersten, Korey R. Haefner, Maria A. Cavasin, Cortney E. Wilson, Mark Y. Jeong, Yu Han, Michael Gotthardt, Scott K. Ferguson, Amrut V. Ambardekar, Maggie P.Y. Lam, Chunaram Choudhary, Henk L. Granzier, Kathleen C. Woulfe, Timothy A. McKinsey   +18 more
doaj   +5 more sources

What Can We Learn from Single Sarcomere and Myofibril Preparations?

Frontiers in Physiology, 2022
Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
doaj   +1 more source

The role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils [PDF]

Royal Society Open Science, 2016
The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a
Kaleena Johnston, Azim Jinha, Walter Herzog   +2 more
doaj   +1 more source

Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure

Biology, 2022
The R249Q mutation in human β-cardiac myosin results in hypertrophic cardiomyopathy. We previously showed that inserting this mutation into Drosophila melanogaster indirect flight muscle myosin yields mechanical and locomotory defects.
William A. Kronert, Karen H. Hsu, Aditi Madan, Floyd Sarsoza, Anthony Cammarato, Sanford I. Bernstein   +5 more
doaj   +1 more source

The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle

Cells, 2023
The maintenance of skeletal muscle mass plays a fundamental role in health and issues associated with quality of life. Mechanical signals are one of the most potent regulators of muscle mass, with a decrease in mechanical loading leading to a decrease in
Ramy K. A. Sayed, Jamie E. Hibbert, Kent W. Jorgenson, Troy A. Hornberger   +3 more
doaj   +1 more source

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

eLife, 2023
Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro, James B Hayes, Zachary C Sanchez, Nilay Taneja, Aidan M Fenix, Satish Moparthi, Stéphane Vassilopoulos, Dylan Tyler Burnette   +7 more
doaj   +1 more source

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

eLife, 2021
Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth.
Aynur Kaya-Çopur, Fabio Marchiano, Marco Y Hein, Daniel Alpern, Julie Russeil, Nuno Miguel Luis, Matthias Mann, Bart Deplancke, Bianca H Habermann, Frank Schnorrer   +9 more
doaj   +1 more source

Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients with repair of tetralogy of Fallot (rToF) who are approaching adulthood often exhibit pulmonary valve regurgitation, leading to right ventricle (RV) dilatation and dysfunction.
Daniel Brayson, So‐Jin Holohan, Sonya C. Bardswell, Matthew Arno, Han Lu, Hanna K. Jensen, Phan Kiet Tran, Javier Barallobre‐Barreiro, Manuel Mayr, Cristobal G. dos Remedios, Victor T. Tsang, Alessandra Frigiola, Jonathan C. Kentish   +12 more
doaj   +1 more source

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

eLife, 2022
Human muscle is a hierarchically organised tissue with its contractile cells called myofibers packed into large myofiber bundles. Each myofiber contains periodic myofibrils built by hundreds of contractile sarcomeres that generate large mechanical forces.
Qiyan Mao, Achyuth Acharya, Alejandra Rodríguez-delaRosa, Fabio Marchiano, Benoit Dehapiot, Ziad Al Tanoury, Jyoti Rao, Margarete Díaz-Cuadros, Arian Mansur, Erica Wagner, Claire Chardes, Vandana Gupta, Pierre-François Lenne, Bianca H Habermann, Olivier Theodoly, Olivier Pourquié, Frank Schnorrer   +16 more
doaj   +1 more source

Assembly and Dynamics of Myofibrils [PDF]

Journal of Biomedicine and Biotechnology, 2010
We review some of the problems in determining how myofibrils may be assembled and just as importantly how this contractile structure may be renewed by sarcomeric proteins moving between the sarcomere and the cytoplasm. We also address in this personal review the recent evidence that indicates that the assembly and dynamics of myofibrils are conserved ...
Sanger, Joseph W., Wang, Jushuo, Fan, Yingli, White, Jennifer, Sanger, Jean M.   +4 more
openaire   +2 more sources