Results 1 to 10 of about 11,807 (115)

Cardiac myofibril networks induce shear stress [PDF]

npj Systems Biology and Applications
Myofibril arrangement is critical to cardiac muscle function in health and disease. Historically, analysis of the impact of myofibril organisation on force and cell contraction has relied on the assumption of uniaxial arrays.
L. A. Murray, A. P. Quinn, C. Pinali, D. J. Collins, V. Rajagopal   +4 more
doaj   +2 more sources

Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc [PDF]

eLife
The Drosophila scaffolding protein Zasp52 is required to maintain structure at the muscle Z-disc, which experiences strong forces during contraction. It is alternatively spliced into many isoforms, some of which contain a long intrinsically disordered ...
Nikolai Ho, Frieder Schöck
doaj   +2 more sources

Force Measurements From Myofibril to Filament

Frontiers in Physiology, 2022
Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
exaly   +3 more sources

What Can We Learn from Single Sarcomere and Myofibril Preparations?

Frontiers in Physiology, 2022
Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
doaj   +1 more source

The role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils [PDF]

Royal Society Open Science, 2016
The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a
Kaleena Johnston, Azim Jinha, Walter Herzog   +2 more
doaj   +1 more source

Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure

Biology, 2022
The R249Q mutation in human β-cardiac myosin results in hypertrophic cardiomyopathy. We previously showed that inserting this mutation into Drosophila melanogaster indirect flight muscle myosin yields mechanical and locomotory defects.
William A. Kronert, Karen H. Hsu, Aditi Madan, Floyd Sarsoza, Anthony Cammarato, Sanford I. Bernstein   +5 more
doaj   +1 more source

The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle

Cells, 2023
The maintenance of skeletal muscle mass plays a fundamental role in health and issues associated with quality of life. Mechanical signals are one of the most potent regulators of muscle mass, with a decrease in mechanical loading leading to a decrease in
Ramy K. A. Sayed, Jamie E. Hibbert, Kent W. Jorgenson, Troy A. Hornberger   +3 more
doaj   +1 more source

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

eLife, 2023
Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro, James B Hayes, Zachary C Sanchez, Nilay Taneja, Aidan M Fenix, Satish Moparthi, Stéphane Vassilopoulos, Dylan Tyler Burnette   +7 more
doaj   +1 more source

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

eLife, 2021
Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth.
Aynur Kaya-Çopur, Fabio Marchiano, Marco Y Hein, Daniel Alpern, Julie Russeil, Nuno Miguel Luis, Matthias Mann, Bart Deplancke, Bianca H Habermann, Frank Schnorrer   +9 more
doaj   +1 more source

Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients with repair of tetralogy of Fallot (rToF) who are approaching adulthood often exhibit pulmonary valve regurgitation, leading to right ventricle (RV) dilatation and dysfunction.
Daniel Brayson, So‐Jin Holohan, Sonya C. Bardswell, Matthew Arno, Han Lu, Hanna K. Jensen, Phan Kiet Tran, Javier Barallobre‐Barreiro, Manuel Mayr, Cristobal G. dos Remedios, Victor T. Tsang, Alessandra Frigiola, Jonathan C. Kentish   +12 more
doaj   +1 more source