Results 1 to 10 of about 21,531 (244)
The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes [PDF]
eLife, 2017 Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive.
Hirohito Shimizu +7 more
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HDAC6 modulates myofibril stiffness and diastolic function of the heart
Journal of Clinical Investigation, 2022 Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin ...
Tim Liebner +2 more
exaly +2 more sources
Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships [PDF]
Frontiers in Cell and Developmental BiologyThe skeletal muscle, one of the largest tissues in mammals, plays a crucial role in maintaining body movement and energy metabolism. Dysfunction or damage to the skeletal muscle can lead to various muscle diseases, such as muscular dystrophy, myasthenia,
Jing Zhao +4 more
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Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy [PDF]
Frontiers in Physiology, 2017 Dilated cardiomyopathy amongst children (pediatric cardiomyopathy, pediatric CM) is associated with a high morbidity and mortality. Because little is known about the pathophysiology of pediatric CM, treatment is largely based on adult heart failure ...
Ilse A. E. Bollen +6 more
doaj +3 more sources
What Can We Learn from Single Sarcomere and Myofibril Preparations?
Frontiers in Physiology, 2022 Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
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The role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils [PDF]
Royal Society Open Science, 2016 The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a
Kaleena Johnston +2 more
doaj +1 more source
Biology, 2022 The R249Q mutation in human β-cardiac myosin results in hypertrophic cardiomyopathy. We previously showed that inserting this mutation into Drosophila melanogaster indirect flight muscle myosin yields mechanical and locomotory defects.
William A. Kronert +5 more
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The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle
Cells, 2023 The maintenance of skeletal muscle mass plays a fundamental role in health and issues associated with quality of life. Mechanical signals are one of the most potent regulators of muscle mass, with a decrease in mechanical loading leading to a decrease in
Ramy K. A. Sayed +3 more
doaj +1 more source
eLife, 2023 Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro +7 more
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eLife, 2021 Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth.
Aynur Kaya-Çopur +9 more
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