Results 21 to 30 of about 13,101 (238)
Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin
Developmental Cell, 2017 International audienceSkeletal muscle contraction is mediated by myofibrils, complex multi-molecular scaffolds structured into repeated units, the sarcomeres.
Sylvain Ernest, Sophie Lemoine
exaly +2 more sources
Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly. [PDF]
PLoS Genetics, 2013 The Drosophila Alp/Enigma family protein Zasp52 localizes to myotendinous junctions and Z-discs. It is required for terminal muscle differentiation and muscle attachment.
Anja Katzemich +3 more
doaj +2 more sources
Increased Hemodynamic Load in Early Embryonic Stages Alters Myofibril and Mitochondrial Organization in the Myocardium [PDF]
Frontiers in Physiology, 2017 Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease (CHD).
Madeline Midgett +5 more
doaj +2 more sources
International audienceMuscle cells contain numerous energy-producing mitochondria and contractile myofibrils, whose myosin motors need ATP to generate force. Thus, myofibrils and mitochondria are in intimate contact in mature muscles.
Avellaneda J +5 more
europepmc +3 more sources
What Can We Learn from Single Sarcomere and Myofibril Preparations?
Frontiers in Physiology, 2022 Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
doaj +1 more source
The role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils [PDF]
Royal Society Open Science, 2016 The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a
Kaleena Johnston +2 more
doaj +1 more source
Biology, 2022 The R249Q mutation in human β-cardiac myosin results in hypertrophic cardiomyopathy. We previously showed that inserting this mutation into Drosophila melanogaster indirect flight muscle myosin yields mechanical and locomotory defects.
William A. Kronert +5 more
doaj +1 more source
The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle
Cells, 2023 The maintenance of skeletal muscle mass plays a fundamental role in health and issues associated with quality of life. Mechanical signals are one of the most potent regulators of muscle mass, with a decrease in mechanical loading leading to a decrease in
Ramy K. A. Sayed +3 more
doaj +1 more source
eLife, 2023 Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro +7 more
doaj +1 more source
eLife, 2021 Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth.
Aynur Kaya-Çopur +9 more
doaj +1 more source