Results 11 to 20 of about 2,944 (198)

The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes [PDF]

eLife, 2017
Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive.
Hirohito Shimizu, Adam D Langenbacher, Jie Huang, Kevin Wang, Georg Otto, Robert Geisler, Yibin Wang, Jau-Nian Chen   +7 more
doaj   +3 more sources

Mechanobiology of muscle and myofibril morphogenesis

Cells & Development, 2021
International audienceMuscles generate forces for animal locomotion. The contractile apparatus of muscles is the sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin springs.
Luis, Nuno Miguel, Schnorrer, Frank, Nuno Miguel Luis, Frank Schnorrer   +3 more
core   +3 more sources

A Novel Method of Isolating Myofibrils From Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study [PDF]

Frontiers in Cardiovascular Medicine, 2019
Myofibril based mechanical studies allow evaluation of sarcomeric protein function. We describe a novel method of obtaining myofibrils from primary cardiomyocyte culture.
Kathleen C. Woulfe, Claudia Ferrara, Jose Manuel Pioner, Jennifer H. Mahaffey, Raffaele Coppini, Beatrice Scellini, Cecilia Ferrantini, Nicoletta Piroddi, Chiari Tesi, Corrado Poggesi, Mark Jeong   +10 more
doaj   +2 more sources

PREPARATION AND CHARACTERISTICS OF PACIFIC CODFISH (Gadus macrocephalus) MYOFIBRIL FOR SURIMI [PDF]

Food ScienTech Journal, 2020
Myofibril is contributing to gel-forming. Every species of fish have different myofibril concentration. Pacific codfish has white flesh which is expected to make surimi. The objective of this research was to analyze the characteristics of surimi prepared
Agustia Dwi Pamujiati, Yuli Witono, Nina Lisanty   +2 more
doaj   +2 more sources

Cardiac myofibril networks induce shear stress

npj Systems Biology and Applications
Myofibril arrangement is critical to cardiac muscle function in health and disease. Historically, analysis of the impact of myofibril organisation on force and cell contraction has relied on the assumption of uniaxial arrays.
L. A. Murray, A. P. Quinn, C. Pinali, D. J. Collins, V. Rajagopal   +4 more
doaj   +3 more sources

Characterizing the actin-binding ability of Zasp52 and its contribution to myofibril assembly.

PLoS ONE, 2020
In sarcomeres, α-actinin crosslinks thin filaments and anchors them at the Z-disc. Drosophila melanogaster Zasp52 also localizes at Z-discs and interacts with α-actinin via its extended PDZ domain, thereby contributing to myofibril assembly and ...
Kuo An Liao, Nicanor González-Morales, Frieder Schöck   +2 more
doaj   +2 more sources

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy [PDF]

Frontiers in Physiology, 2017
Dilated cardiomyopathy amongst children (pediatric cardiomyopathy, pediatric CM) is associated with a high morbidity and mortality. Because little is known about the pathophysiology of pediatric CM, treatment is largely based on adult heart failure ...
Ilse A. E. Bollen, Marijke van der Meulen, Kyra de Goede, Diederik W. D. Kuster, Michiel Dalinghaus, Jolanda van der Velden, Jolanda van der Velden   +6 more
doaj   +3 more sources

Shrinkage Properties and Their Relationship with Degradation of Proteins Linking the Endomysium and Myofibril in Lamb Meat Submitted to Heating or Air Drying

Foods, 2022
The shrinkage of the connective tissue and myofiber of lamb meat submitted to heat treatment or air drying at different storage stages (1, 5 and 7 days) was evaluated herein. The longitudinal and transverse shrinkage of heated lamb meat was significantly
Weili Rao, Zhenxiao Shi, Sijia Liu, Ying Shu, Xiaoyu Chai, Zhisheng Zhang   +5 more
doaj   +2 more sources

Multi-omics insight into cardiac myofibril remodeling in post-prandial Burmese pythons [PDF]

Communications Biology
Burmese pythons exhibit cardiac remodeling in response to increased metabolic rate during digestion. Here, we performed single-myofibril mechanics measurements and myosin biochemical assays to evaluate the impact of feeding on the cardiomyocyte sarcomere
Thomas G. Martin, Lorena Suarez-Artiles, Kathleen C. Woulfe, Elise G. Melhedegaard, Yuxiao Tan, Dakota R. Hunt, Bruce E. Kirkpatrick, Lia Nguyen, Joseph Lee, Isabella Laskey, Kristi S. Anseth, Julien Ochala, Michael Gotthardt, Philipp Mertins, Leslie A. Leinwand   +14 more
doaj   +2 more sources

effect of ascorbic acid on gel formation of myofibril from big eye scad fish (Selar crumenophthalnus)

Jurnal Teknologi dan Industri Pangan, 2010
Effect of ascorbic acid on gel formation of myofibril from big eye scad fish (Selar crumenophthalnus)were studied for its development as food ingredient.
Achmad Subagio, Wiwik siti Windrati, Mukhamad Fauzi, Yuli Witono   +3 more
doaj   +1 more source