Cardiac myofibril networks induce shear stress [PDF]
npj Systems Biology and ApplicationsMyofibril arrangement is critical to cardiac muscle function in health and disease. Historically, analysis of the impact of myofibril organisation on force and cell contraction has relied on the assumption of uniaxial arrays.
L. A. Murray +4 more
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HDAC6 modulates myofibril stiffness and diastolic function of the heart [PDF]
The Journal of Clinical Investigation, 2022 Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin ...
Ying-Hsi Lin +18 more
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Force–length relation of skeletal muscles: from sarcomeres to myofibril [PDF]
Biomechanics and Modeling in Mechanobiology, 2018 Sarcomeres are building blocks of skeletal muscles. Given force–length relations of sarcomeres serially connected in a myofibril, the myofibril force–length relation can be uniquely determined.
M Hou
exaly +2 more sources
Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles. [PDF]
PLoS ONE, 2014 BACKGROUND:Smyd1, the founding member of the Smyd family including Smyd-1, 2, 3, 4 and 5, is a SET and MYND domain containing protein that plays a key role in myofibril assembly in skeletal and cardiac muscles.
Jie Gao +5 more
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A Novel Method of Isolating Myofibrils From Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study [PDF]
Frontiers in Cardiovascular Medicine, 2019 Myofibril based mechanical studies allow evaluation of sarcomeric protein function. We describe a novel method of obtaining myofibrils from primary cardiomyocyte culture.
Kathleen C. Woulfe +10 more
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The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes [PDF]
eLife, 2017 Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive.
Hirohito Shimizu +7 more
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Characterizing the actin-binding ability of Zasp52 and its contribution to myofibril assembly.
PLoS ONE, 2020 In sarcomeres, α-actinin crosslinks thin filaments and anchors them at the Z-disc. Drosophila melanogaster Zasp52 also localizes at Z-discs and interacts with α-actinin via its extended PDZ domain, thereby contributing to myofibril assembly and ...
Kuo An Liao +2 more
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PREPARATION AND CHARACTERISTICS OF PACIFIC CODFISH (Gadus macrocephalus) MYOFIBRIL FOR SURIMI [PDF]
Food ScienTech Journal, 2020 Myofibril is contributing to gel-forming. Every species of fish have different myofibril concentration. Pacific codfish has white flesh which is expected to make surimi. The objective of this research was to analyze the characteristics of surimi prepared
Agustia Dwi Pamujiati +2 more
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Mechanobiology of muscle and myofibril morphogenesis
Cells & Development, 2021 International audienceMuscles generate forces for animal locomotion. The contractile apparatus of muscles is the sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin springs.
Luis, Nuno Miguel, Schnorrer, Frank
core +3 more sources
Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy [PDF]
Frontiers in Physiology, 2017 Dilated cardiomyopathy amongst children (pediatric cardiomyopathy, pediatric CM) is associated with a high morbidity and mortality. Because little is known about the pathophysiology of pediatric CM, treatment is largely based on adult heart failure ...
Ilse A. E. Bollen +6 more
doaj +3 more sources