Results 31 to 40 of about 35,307 (294)

Cardiac Sarcomere Signaling in Health and Disease

, 2022
The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs. This review focuses on the
Hosny, Nora, Cohen, Houda, Brian R. Thompson, Thompson, Brian R., Houda Cohen, Dongwoo Hahn, Nora Hosny, Joseph M. Metzger, Martin, Ashley A., Addeli Bez Batti Angulski, Metzger, Joseph M., Hahn, Dongwoo, Angulski, Addeli Bez Batti, Ashley A. Martin   +13 more
core   +1 more source

Biomechanical Properties of Paraspinal Muscles Influence Spinal Loading—A Musculoskeletal Simulation Study

Frontiers in Bioengineering and Biotechnology, 2022
Paraspinal muscles are vital to the functioning of the spine. Changes in muscle physiological cross-sectional area significantly affect spinal loading, but the importance of other muscle biomechanical properties remains unclear.
Masoud Malakoutian, Masoud Malakoutian, C. Antonio Sanchez, Stephen H. M. Brown, John Street, John Street, Sidney Fels, Thomas R. Oxland, Thomas R. Oxland, Thomas R. Oxland   +9 more
doaj   +1 more source

Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy [PDF]

Gene, 2016
Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers. Several genes encoding heart sarcomeric proteins have been associated to HCM, but a small proportion of HCM patients harbor alterations in other non-sarcomeric loci.
BOTTILLO, IRENE, D'ANGELANTONIO, DANIELA, CAPUTO, VIVIANA, PAIARDINI, ALESSANDRO, LIPARI, MARTINA, De Bernardo, C, Giannarelli, D, PIZZUTI, Antonio, Majore, S, Castori, M, Zachara, E, Re, F, GRAMMATICO, Paola   +12 more
openaire   +3 more sources

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

eLife, 2015
Truncating mutations in the giant sarcomeric protein Titin result in dilated cardiomyopathy and skeletal myopathy. The most severely affected dilated cardiomyopathy patients harbor Titin truncations in the C-terminal two-thirds of the protein, suggesting
Jun Zou, Diana Tran, Mai Baalbaki, Ling Fung Tang, Annie Poon, Angelo Pelonero, Erron W Titus, Christiana Yuan, Chenxu Shi, Shruthi Patchava, Elizabeth Halper, Jasmine Garg, Irina Movsesyan, Chaoying Yin, Roland Wu, Lisa D Wilsbacher, Jiandong Liu, Ronald L Hager, Shaun R Coughlin, Martin Jinek, Clive R Pullinger, John P Kane, Daniel O Hart, Pui-Yan Kwok, Rahul C Deo   +24 more
doaj   +1 more source

Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review

Cells, 2020
The maintenance of skeletal muscle mass plays a critical role in health and quality of life. One of the most potent regulators of skeletal muscle mass is mechanical loading, and numerous studies have led to a reasonably clear understanding of the ...
Kent W. Jorgenson, Stuart M. Phillips, Troy A. Hornberger   +2 more
doaj   +1 more source

Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

Biomedicines, 2022
The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative stress,
Amal F. Dawood, Norah M. Alzamil, Peter W. Hewett, Maha A. Momenah, Mohammad Dallak, Samaa S. Kamar, Dina H. Abdel Kader, Hanaa Yassin, Mohamed A. Haidara, Amro Maarouf, Bahjat Al-Ani   +10 more
doaj   +1 more source

Targets for therapy in sarcomeric cardiomyopathies [PDF]

Cardiovascular Research, 2015
To date, no compounds or interventions exist that treat or prevent sarcomeric cardiomyopathies. Established therapies currently improve the outcome, but novel therapies may be able to more fundamentally affect the disease process and course. Investigations of the pathomechanisms are generating molecular insights that can be useful for the design of ...
Tardiff JC, Carrier L, Bers DM, POGGESI, CORRADO, FERRANTINI, CECILIA, COPPINI, RAFFAELE, Maier LS, Ashrafian H, Huke S, van der Velden J.   +9 more
openaire   +6 more sources

Gaining new understanding of sarcomere length non-uniformities in skeletal muscles

Frontiers in Physiology
Sarcomere lengths are non-uniform on all structural levels of mammalian skeletal muscle. These non-uniformities have been associated with a variety of mechanical properties, including residual force enhancement and depression, creep, increased force ...
Meng Li, T. R. Leonard, S. W. Han, E. K. Moo, E. K. Moo, E. K. Moo, W. Herzog   +6 more
doaj   +1 more source

Frequency-dependent signaling in cardiac myocytes

Frontiers in Physiology, 2022
Background: Recent experimental data support the view that signaling activity at the membrane depends on its geometric parameters such as surface area and curvature.
Payam Haftbaradaran Esfahani, Jan Westergren, Lennart Lindfors, Ralph Knöll, Ralph Knöll   +4 more
doaj   +1 more source

Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells [PDF]

American Journal of Physiology-Cell Physiology, 2017
Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal ...
openaire   +2 more sources